We are grateful to the federal and state government agencies, foundations, universities, and companies who have funded our research on nanovaccines, nanotherapeutics, and nanoparticles. Here is a partial list of our recent sponsored projects, showing the project title, principal investigator (PI) and co-investigators (COIs), award number, and project dates. Nanovaccine Institute researchers are marked in bold.
Current Awards
Department of Defense
“Nanomedicine countermeasures to overcome antimicrobial resistance”
B Bellaire, PI; B Narasimhan, COI 12/18–12/21
National Institutes of Health
“Universal room temperature stable influenza nanovaccine”
B Narasimhan, PI; S Mallapragada, M Wannemuehler, D Verhoeven, M Kohut, B Sponseller, K Legge, COIs 01/19–12/23
“Nanovaccine platforms to combat pancreatic cancer”
B Narasimhan, PI; M Jain, A Salem, M Wannemuehler, COIs 09/17–08/22
“Nanovaccine-mediated immune protection against influenza virus”
K Legge, PI; T Waldschmidt, B Narasimhan, T Friedrich, COIs 06/17–05/22
“Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity”
AG Kanthasamy, PI; A Kanthasamy, COI 04/16–03/21
“Modeling the Coupled Dynamics of Influenza Transmission and Vaccination Behavior”
R Vardavas, PI; A Parker, COI 02/16–01/21
“Exosomes and Neuroinflammation in Parkinson’s Disease”
A Kanthasamy, PI; AG Kanthasamy, COI 02/15–11/19
National Science Foundation
“On-chip studies of neuron cells under magnetic field stimulation”
Q Long, PI; D Jiles, I Schneider, COIs 06/16–05/20
U.S. Department of Agriculture
“Optimizing an immunocastration vaccine ear implant to prevent pain associated with bovine castration”
J Coetzee, PI; D Jones, B Narasimhan, COIs 09/17–08/20
“Optimization and testing of a universal influenza vaccine for swine”
D Verhoeven, PI 06/17–05/20
Foundations, Associations
Howard Hughes Medical Institute
“Integrated Education and Research Program in Nanomedicine”
S Mallapragada, PI 01/18–12/20
Companies
Merck & Company Inc.
“Pulsatile release of multiple vaccine payloads from polyanhydride nanoparticles”
B Narasimhan, PI; M Wannemuehler, COI 02/19–04/20
Recently Completed Awards (ended within last five years)
Department of Defense
“Novel Approaches for Detecting Gene Amplifications”
G Phillips, PI; S Pandey, E Yu, COIs 10/14–09/16
“INNS: Integrated Neuroprotective and Neuroregenerative Strategies”
S Mallapragada, PI; A Kanthasamy, B Narasimhan, D Sakaguchi, M Wannemuehler, COIs 08/11–05/16
“Targeted Nanovaccine Platforms Against Respiratory Pathogens”
S Mallapragada, PI; S Carpenter, B Narasimhan, N Pohl, M Wannemuehler, COIs 09/10–09/14
Health Resources and Services Administration
“INOVA: Interdisciplinary Laboratory for Design, Discovery, and Testing of Vaccines and Anti-Microbials”
B Narasimhan, PI; P Nara, M Wannemuehler, COIs 08/10–12/14
National Institutes of Health
“Enhanced Shelf-life Nanovaccine Formulation for Immunity to Biodefense Pathogens”
B Narasimhan, PI; M Wannemuehler, B Bellaire, J Hostetter, T Dubensky, COIs 09/14–08/19
“Role of Mitochondria-Targeted CYP2D6 in Chemical Toxicity”
AG Kanthasamy, COI 02/15–12/18
“Stucture and Mechanism of the AbgT-family Transporters”
E Yu, PI; R Jernigan, COI 09/15–08/18
“Highly Simplified Model of a Mammalian Intestinal Community”
G Phillips, PI; J Hostetter, A Jergens, M Wannemuehler, COIs 12/12–11/17
“Function and Inhibition of Multidrug Efflux Systems in Campylobacter”
Q Zhang, PI; E Yu, COI 12/15–11/17
“Structure and Mechanism of the ABGT-Family Transporters”
E Yu, PI; R Jernigan, COI 09/15–08/17
“Mechanism and Engineering of IGG-Based Monoclonal Antibody/Receptor Interactions”
A Barb, PI 08/15–06/17
“Mechanisms of Manganese Neurotoxicity”
AG Kanthasamy, PI; A Kanthasamy, COI 09/10–04/17
“Prokineticin 2 and Neuroinflammatory Mechanisms”
A Kanthasamy, PI; AG Kanthasamy, V Anantharam, COIs 05/12–04/17
“Oxidative Stress Induced Compensatory Protective Mechanisms in Parkinson’s Disease”
AG Kanthasamy, PI; V Anantharam, COI 06/11–03/17
“Mtb Regulators of Essential and Virulence-Associated MmpLs”
G Purdy, PI; E Yu, COI 08/15–07/16
“Strategies of Lentivirus Persistence”
S Carpenter, PI; K Dorman, COI 08/09–01/15
“NMR Studies on the Role of the Essential IGG N-Glycan in Immune System Activation”
A Barb, PI 01/13–12/14
“Enhancing B Cell Immunity Against HIV-1 Using Novel Vaccine Delivery Platforms”
M Cho, PI; B Narasimhan, COI 08/10–07/14
National Science Foundation
“Planning Grant: Engineering Research Center for Aging-centric Engineering Technologies (AgETech)”
B Narasimhan, PI; R Jain, T Lockhart, J Margrett, C Hertzog, COIs 09/19–08/19
“Cases for Teaching Responsible Communication of Science”
J Goodwin, PI; M Dahlstrom, M Kemis, J Wolf, COIs 09/12–08/15
“REU Site: Biological Materials and Processes (BIOMAP)”
M Lamm, PI; B Narasimhan, COI 03/12–02/15
“BRIGE: Reprogramming Tumor Associated Macrophages: Engineering Polymer Surface Properties to Discriminately Deliver Drugs”
K Bratlie, PI 09/12–08/14
U.S. Department of Agriculture
“Next Generation Polyanhydride Nanovaccine Platform Technology for Poultry”
A Talaat, PI; B Narasimhan, COI 01/16–03/19
“Nanoparticle Delivery of Antibiotics for Disease Control in Cultured Shrimp”
L Bartholomay, PI; B Narasimhan and B Bellaire, Co-PIs 03/15–03/18
“Advancing the Understanding of the Zoonotic Risk of ExPECs and Evaluation of a Vaccine to Control these Contaminants in Poultry Production”
M Mellata, PI 09/15–03/17
“Development of New Vaccine Platforms and Constructs for Respiratory Viruses”
B Narasimhan, PI; M Wannemuehler, COI 07/12–05/15
Foundations, Associations
PhRMA Foundation
“Develop Oral Vaccines with Miniguts”
Q Wang, PI 07/17–06/18
Crohns and Colitis Foundation
“Targeted Delivery of Intestinal Stem Cells to Treat Inflammatory Bowel Disease”
Q Wang, PI 07/15–06/18
Iowa Veterinary Medical Association
“Rapid Evaluation for Efficacy of Vaccines for Mycobacterium Avium SS Paratuberculosis in Cattle”
J Hostetter, PI; D Jones, COI 01/17–12/17
National Pork Board
“Efficacy of a Novel Intramammary Vaccine Delivery System for PEDV to Decrease Pre-weaning Mortality and Enhance Mechanisms of Immunity”
B Arruda, PI; P Arruda, D Jones, B Narasimhan, K Schwartz, J Zhang, COIs 12/16–12/17
Found Animals Foundation
“Development of a Vaccine Delivery Device That Will Maintain Life-Long High Titers of Anti-GNRH Antibodies”
D Jones, PI 05/12–05/16
Foundation for the National Institutes of Health
“Molecular Mosquitocides: Development of an innovative and robust, platform-based approach for sustainable insecticidal control of Anopheline mosquitoes”
L Bartholomay, PI 08/11–06/15
Bill and Melinda Gates Foundation
“Combination Anti-Filarial Treatments Using Amphiphilic Micro- and Nanoparticles”
B Bellaire, PI; R Martin, B Narasimhan, COIs 05/13–10/14
Universities
University of North Texas
“Sleep and Vaccine Response in Nurses”
M Kohut, PI 12/16–11/17
Iowa State University
“Presidential Initiative for Interdisciplinary Research: Systems Design of Nanovaccines”
B Narasimhan, PI; S Carpenter, M Wannemuehler, T Dubensky, R Silberglitt, COIs 07/13–06/16
Iowa State University, Regents Innovation Fund
“Evaluation of α-Synuclein immunotherapeutics in animal model of Parkinson’s disease, Phase II”
B Narasimhan, PI; V Anatharam, M John, COIs 07/15–05/16
Iowa State University, Regents Innovation Fund
“Evaluation of α-Synuclein immunotherapeutics in animal model of Parkinson’s disease”
B Narasimhan, PI; V Anatharam, M John, COIs 09/14–05/15
Companies
Triton Systems Inc.
“A Long-Term Anti-Malarial Drug-Releasing Implant”
B Narasimhan, PI 02/19–07/19
Merck & Company Inc.
“Investigation of a Candidate Universal Influenza Vaccine Targeting the HA Head”
D Verhoeven, PI; B Lee, B Sponseller, COIs 10/16–10/18
Merck & Company Inc.
“Investigation of Antibiotic-Resistant S. Pneumoniae Pathogenesis in a Unique Co-Infection Model”
D Verhoeven, PI; B Lee, M Ackermann, E Yu, COIs 11/16–10/18
3M
“Second Harmonic Generation Imaging of Collagen Fiber Orientation as a Marker for Scarring”
K Bratlie, PI 11/16–11/17
Entera Health Inc.
“Evaluation of SBI using the ASF Gnotobiotic Mouse Model of Colitis”
M Wannemuehler, PI; J Hostetter, A Jergens, G Phillips, COIs 03/14–02/15