We are grateful to the federal and state government agencies, foundations, universities, and companies who have funded our research on nanovaccines, nanotherapeutics, and nanoparticles. Here is a partial list of our recent sponsored projects, showing the project title, principal investigator (PI) and co-investigators (COIs), award number, and project dates. Nanovaccine Institute researchers are marked in bold.
Current Awards
National Institutes of Health (NIH)
“Nanovaccine Platforms to Combat Pancreatic Cancer”
B Narasimhan, PI; M Jain, A Salem, M Wannemuehler, COIs U01CA213862 9/17–8/22
“Nanovaccine-Mediated Immune Protection Against Influenza Virus”
K Legge, PI; T Waldschmidt, B Narasimhan, COIs R01AI127565 6/17–5/22
“Modeling the Coupled Dynamics of Influenza Transmission and Vaccination Behavior”
R Vardavas, PI; A Parker, COI R01AI118705 2/16–1/21
“Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity”
AG Kanthasamy, PI; A Kanthasamy, COI R01ES026892 4/16–3/21
“Exosomes and Neuroinflammation in Parkinson’s Disease”
A Kanthasamy, PI; AG Kanthasamy, COI R01NS088206 2/15–11/19
“Role of Mitochondria-Targeted CYP2D6 in Chemical Toxicity”
AG Kanthasamy, COI R01GM034883-27AI 2/15–12/18
“Enhanced Shelf-life Nanovaccine Formulation for Immunity to Biodefense Pathogens”
B Narasimhan, PI; M Wannemuehler, B Bellaire, J Hostetter, T Dubensky, COIs R01AI111466 9/14–8/18
“Stucture and Mechanism of the AbgT-family Transporters”
E Yu, PI; R Jernigan, COI R01AI114629 9/15–8/18
“Highly Simplified Model of a Mammalian Intestinal Community”
G Phillips, PI; J Hostetter, A Jergens, M Wannemuehler, COIs R01GM099537 12/12–11/17
“Function and Inhibition of Multidrug Efflux Systems in Campylobacter”
Q Zhang, PI; E Yu, COI R01AI118283 12/15–11/17
U.S. Department of Agriculture (USDA)
“Nanoparticle Delivery of Antibiotics for Disease Control in Cultured Shrimp”
L Bartholomay, PI; B Narasimhan and B Bellaire, Co-PIs 20156702123309 3/15–3/18
“Next Generation Polyanhydride Nanovaccine Platform Technology for Poultry”
A Talaat, PI; B Narasimhan, COI 20166702125042 1/16–12/19
Foundations, Associations
PhRMA Foundation
“Develop Oral Vaccines with Miniguts”
Q Wang, PI 7/17–6/18
Crohns and Colitis Foundation
“Targeted Delivery of Intestinal Stem Cells to Treat Inflammatory Bowel Disease”
Q Wang, PI 348137 7/15–6/18
Iowa Veterinary Medical Association
“Rapid Evaluation for Efficacy of Vaccines for Mycobacterium Avium SS Paratuberculosis in Cattle”
J Hostetter, PI; D Jones, COI 1/17–12/17
National Pork Board
“Efficacy of a Novel Intramammary Vaccine Delivery System for PEDV to Decrease Pre-weaning Mortality and Enhance Mechanisms of Immunity”
B Arruda, PI; P Arruda, D Jones, B Narasimhan, K Schwartz, J Zhang, COIs 16036 12/16–12/17
Universities
University of North Texas
“Sleep and Vaccine Response in Nurses”
M Kohut, PI GF000041 12/16–11/17
Companies
Merck & Company Inc.
“Investigation of a Candidate Universal Influenza Vaccine Targeting the HA Head”
D Verhoeven, PI; B Lee, B Sponseller, COIs 54786 10/16–10/18
Merck & Company Inc.
“Investigation of Antibiotic-Resistant S. Pneumoniae Pathogenesis in a Unique Co-Infection Model”
D Verhoeven, PI; B Lee, M Ackermann, E Yu, COIs 55211 11/16–10/18
3M
“Second Harmonic Generation Imaging of Collagen Fiber Orientation as a Marker for Scarring”
K Bratlie, PI 11/16–11/17
Recently Completed Awards
Department of Defense (DOD)
“Novel Approaches for Detecting Gene Amplifications”
G Phillips, PI; S Pandey, E Yu, COIs 10/14–9/16
“INNS: Integrated Neuroprotective and Neuroregenerative Strategies”
S Mallapragada, PI; A Kanthasamy, B Narasimhan, D Sakaguchi, M Wannemuehler, COIs W81XWH1110700 8/11–5/16
“Targeted Nanovaccine Platforms Against Respiratory Pathogens”
S Mallapragada, PI; S Carpenter, B Narasimhan, N Pohl, M Wannemuehler, COIs W81XWH1010906 9/10–9/14
“Synthetic Nanovaccines Against Respiratory Pathogens”
S Mallapragada, PI; B Narasimhan, M Wannemuehler, COIs 3520052016001 7/09–6/13
“Novel Therapies for Pneumonic Plague Targeting Quorum Sensing Components”
F Minion, PI; B Narasimhan, D Nordman, G Phillips, K Rajan, M Wannemuehler, COIs N000140611176 9/06–3/13
Health Resources and Services Administration (HRSA)
“INOVA: Interdisciplinary Laboratory for Design, Discovery, and Testing of Vaccines and Anti-Microbials”
B Narasimhan, PI; P Nara, M Wannemuehler, COIs C76HF19578 8/10–12/14
National Institutes of Health (NIH)
“Structure and Mechanism of the ABGT-Family Transporters”
E Yu, PI; R Jernigan, COI R01AI114629 9/15–8/17
“Mechanism and Engineering of IGG-Based Monoclonal Antibody/Receptor Interactions”
A Barb, PI R01GM115489 8/15–6/17
“Mechanisms of Manganese Neurotoxicity”
AG Kanthasamy, PI; A Kanthasamy, COI R01ES10586 9/10–4/17
“Prokineticin 2 and Neuroinflammatory Mechanisms”
A Kanthasamy, PI; AG Kanthasamy, V Anantharam, COIs R01NS078247 5/12–4/17
“Oxidative Stress Induced Compensatory Protective Mechanisms in Parkinson’s Disease”
AG Kanthasamy, PI; V Anantharam, COI R01NS074443 6/11–3/17
“Mtb Regulators of Essential and Virulence-Associated MmpLs”
G Purdy, PI; E Yu, COI R56AI114664 8/15–7/16
“Strategies of Lentivirus Persistence”
S Carpenter, PI; K Dorman, COI R01CA128568 8/09–1/15
“NMR Studies on the Role of the Essential IGG N-Glycan in Immune System Activation”
A Barb, PI 1K22AI099165 1/13–12/14
“Enhancing B Cell Immunity Against HIV-1 Using Novel Vaccine Delivery Platforms”
M Cho, PI; B Narasimhan, COI U19AI091031 8/10–7/14
“Metal Ion Export in Bacteria”
E Yu, PI R01GM086431 7/10–6/14
“Role of Prion Protein in Manganese Neurotoxicity”
A Kanthasamy, PI; S Sivasankar, COI R01ES019267 7/10–5/14
“Impact of Polymer Adjuvant Chemistry on Adaptive Immune Mechanisms”
B Narasimhan, PI; B Bellaire, M Wannemuehler, COIs AI075026 8/10–6/13
“Role of Pathogen-Derived Capping Carbohydrates in Altering Immunity”
C Petersen, PI; J Hostetter, N Pohl, COIs 3R21AI074711 8/10–6/11
“Developing Pulmonary Immunocompetency: Focus on the Neonate”
B Sponseller, PI 1R15HL103488 4/10–3/13
“Methods for Automated Syntheses of Oligosaccharides and Lectin Tags”
N Pohl, PI; C Petersen, COI R01GM090280 9/09–6/12
“Neuroinflammatory Mechanisms in the Progression of Parkinson’s Disease”
A Kanthasamy, PI; AG Kanthasamy, COI 5R01NS065167 2/09–1/14
“Mechanisms of Antibiotic Efflux in Campylobacter”
Q Zhang, PI; E Yu, COI 5R01DK063008 8/07–5/13
“Exercise-Induced Immunomodulation in the Aged: Mechanisms”
M Kohut, PI; J Cunnick, D Nettleton, M Wannemuehler, K Yoon, COIs 5R01AI059455 3/07–2/13
“Mechanisms of Manganese Neurotoxicity”
AG Kanthasamy, PI 5R01ES010586 9/06–8/11
National Science Foundation (NSF)
“BRIGE: Reprogramming Tumor Associated Macrophages: Engineering Polymer Surface Properties to Discriminately Deliver Drugs”
K Bratlie, PI CBET1227867 9/12–8/14
“Cases for Teaching Responsible Communication of Science”
J Goodwin, PI; M Dahlstrom, M Kemis, J Wolf, COIs SES1237495 9/12–8/15
“REU Site: Biological Materials and Processes (BIOMAP)”
M Lamm, PI; B Narasimhan, COI EEC1156933 3/12–2/15
“A Platform-Based Approach to Developing and Delivering Nanoparticle Antivirals for Disease Control in Farmed Shrimp”
L Bartholomay, PI; S Quisenberry, COI IIP1114370 7/11–6/14
“A 21st Century Revitalized Research and Research Training Infrastructure for Chemical and Biological Engineering”
S Mallapragada, PI; R Fox, B Narasimhan, B Shanks, J Shanks, COIs CMMI0963224 10/10–9/13
“MRI: Acquisition of a 600-Mhz NMR Spectrometer for Chemical, Nanochemical, and Materials Science Research”
N Pohl, PI; M Jeffries-El, S Mallapragada, A Sadow, J Verkade, COIs CHE1040098 10/10–9/13
“Molecular Design of Nano-carrier Materials for Reactions Catalyzed by Multi-Enzyme Complexes”
S Mallapragada, PI; B Narasimhan, R Peters, COIs CBET0932517 10/09–9/13
“Meshing Synthesis and Biosynthesis for KDO: A Key Plant and Bacterial Sugar”
N Pohl, PI CHE0911123 9/09–9/12
“REU Site: Biological Materials and Processes”
B Narasimhan, PI; M Lamm, COI EEC0851519 5/09–4/12
U.S. Department of Agriculture (USDA)
“Advancing the Understanding of the Zoonotic Risk of ExPECs and Evaluation of a Vaccine to Control these Contaminants in Poultry Production”
M Mellata, PI 20116700525080 9/15–3/17
“Development of New Vaccine Platforms and Constructs for Respiratory Viruses”
B Narasimhan, PI; M Wannemuehler, COI 5836252640 7/12–5/15
“Research Support Agreements”
M Wannemuehler, PI 5836252315 10/11–9/13
“Development and Testing of Vaccine Candidates for Mycobacterium Avium subsp. Paratuberculosis”
M Wannemuehler, PI 5836251733 7/11–12/13
Iowa Department of Public Health
“Epidemiology and Laboratory Capacity for Infectious Diseases”
L Bartholomay, PI 5883EL01 1/12–12/12
“Epidemiology and Laboratory Capacity–West Nile Virus Surveillance”
L Bartholomay, PI 5882EL01 1/11–12/11
“Monitoring Mosquitoes and Vectorborne Diseases”
L Bartholomay, PI 5881EL07 7/10–6/11
Foundations, Associations
Found Animals Foundation
“Development of a Vaccine Delivery Device That Will Maintain Life-Long High Titers of Anti-GNRH Antibodies”
D Jones, PI 5/12–5/16
Foundation for the National Institutes of Health
“Molecular Mosquitocides: Development of an innovative and robust, platform-based approach for sustainable insecticidal control of Anopheline mosquitoes”
L Bartholomay, PI 8/11–6/15
Bill and Melinda Gates Foundation
“Combination Anti-Filarial Treatments Using Amphiphilic Micro- and Nanoparticles”
B Bellaire, PI; R Martin, B Narasimhan, COIs OPP1087610 5/13–10/14
Iowa State University Research Foundation
“Biocompatibility Feasibility Study for Wear-Resistant Borides”
K Bratlie, PI 2350/3582 1/12–8/12
Iowa State University Research Foundation
“Nanoparticle Delivery of Antibiotics for the Treatment of Brucellosis”
B Bellaire, PI 3729 12/11–6/12
Infectious Disease Research Institute
“Leishmania Antigens Defined by Human Immune Responses”
C Petersen, PI; D Jones, COI B12SUB2010 7/10–6/11
Universities
Iowa State University
“Presidential Initiative for Interdisciplinary Research: Systems Design of Nanovaccines”
B Narasimhan, PI; S Carpenter, M Wannemuehler, T Dubensky, R Silberglitt, COIs 7/13–6/16
Iowa State University, Regents Innovation Fund
“Evaluation of α-Synuclein immunotherapeutics in animal model of Parkinson’s disease, Phase II”
B Narasimhan, PI; V Anatharam, M John, COIs 7/15–5/16
Iowa State University, Regents Innovation Fund
“Evaluation of α-Synuclein immunotherapeutics in animal model of Parkinson’s disease”
B Narasimhan, PI; V Anatharam, M John, COIs 9/14–5/15
Colorado State University
“Molecular Mosquitocides: Innovative and Sustainable Control of Malaria Vectors”
L Bartholomay, PI G54411 7/11–6/14
Medical College of Wisconsin
“Neuroprotection by Mitochondria-Targeted Antioxidants”
AG Kanthasamy, PI 1320268 2/11–1/13
University of North Texas
“Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response?”
M Kohut, PI GF26381 2/11–12/13
Medical College of Wisconsin
“Testing of Novel Anti-inflammatory Compounds for Parkinson’s Disease”
AG Kanthasamy, PI 1215394 7/10–6/12
Kansas State University
“Vector Borne Transmission of Leishmania Infantum in the United States”
C Petersen, PI S11007 6/10–5/13
Companies
Entera Health Inc.
“Evaluation of SBI using the ASF Gnotobiotic Mouse Model of Colitis”
M Wannemuehler, PI; J Hostetter, A Jergens, G Phillips, COIs 3/14–2/15
Boehringer Ingelheim Vetmedica Inc.
“Use of PRRS MLV Vaccine to Preserve Antimicrobial Efficiency During PRRS Challenge”
L Karriker PI; J Coetzee, J Ellingson, COIs 3/13–2/14
Life Technologies Corp.
“Evaluation of Novel ROS and Lipid Peroxidation Sensors for Determining Oxidative Damage in Animal Models of Parkinson’s Disease”
AG Kanthasamy, PI 6/12–12/12
Lucella Biosciences Inc.
“Solution-Phase Automated Synthesis of Oligosaccharides”
J Petrich, PI, N Pohl, COI 3/10–2/12
Fluorous Technologies Inc.
“Fluorous Solution-Phase Synthesis of Peptides and Oligosaccharides”
N Pohl, PI 9/09–8/11