Nanovaccine Institute

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You are here: Home / About / Funding

Funding

We are grateful to the federal and state government agencies, foundations, universities, and companies who have funded our research on nanovaccines, nanotherapeutics, and nanoparticles. Here is a partial list of our recent sponsored projects, showing the project title, principal investigator (PI) and co-investigators (C0-Is), and project dates. Nanovaccine Institute researchers are marked in bold.

Current Awards

Department of Defense

“High-throughput metabolic spectral imaging to predict response to therapy in colorectal cancer”
R Bardhan, PI     09/20–08/22

“IL-1 based immunotherapy in head and neck squamous cell carcinoma”
A Burnett, PI; B Narasimhan, Co-I     05/20–02/24

“Multiplexed immunomarker screening to enable patient-tailored immunotherapies”
R Bardhan, PI     03/20–08/22

“Nanomedicine countermeasures to overcome antimicrobial resistance”
B Bellaire, PI; B Narasimhan, C0-I     12/18–12/21

Department of Energy

“Nanozyme aptasensor diagnostic assay for detecting SARS-Cov-2”
R Bardhan, PI     07/20–11/20

National Institutes of Health

“Developing multimodal multiplexed immunoPET-Raman probes to guide immunotherapies”
R Bardhan, PI     09/20–08/25

“PRADA: Portable Reusable Accurate Diagnostics with nanoAntennas for Multiplexed Biomarker Screening of Preterm Labor”
R Bardhan, PI     09/20–08/22

“Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer”
S Rachagani, PI; S Mallapragada, Co-I     08/20–04/25

“Development of a mucosal, polyanhydride-based nanoparticle vaccine for use against RSV infection in the neonate”
J McGill & R Sacco, PIs; B Narasimhan, E Nicholson, Co-Is     09/19–07/23

“Universal room temperature stable influenza nanovaccine”
B Narasimhan, PI; S Mallapragada, M Wannemuehler, D Verhoeven, M Kohut, B Sponseller, K Legge, L Cabell, K Carson, T Sullivan, Co-Is     01/19–12/23

“Nanovaccine platforms to combat pancreatic cancer”
B Narasimhan, PI; M Jain, A Salem, M Wannemuehler, Co-Is     09/17–08/22

“Nanovaccine-mediated immune protection against influenza virus”
K Legge, PI; T Waldschmidt, B Narasimhan, T Friedrich, Co-Is     06/17–05/22

“Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity”
AG Kanthasamy, PI; A Kanthasamy, Co-I     04/16–03/21

“Modeling the Coupled Dynamics of Influenza Transmission and Vaccination Behavior”
R Vardavas, PI; A Parker, Co-I     02/16–01/21

U.S. Department of Agriculture

“Intracellular killing and biofilm destruction of MDR Salmonella by NK-Lysin encapsulated nanoparticles”
R Dassanayake, PI; B Narasimhan, Co-I     09/20–12/20

“Interleuken-17 as a target of therapeutic intervention for bovine respiratory disease”
J McGill, PI     08/19–07/22

“Optimizing an immunocastration vaccine ear implant to prevent pain associated with bovine castration”
J Coetzee, PI; D Jones, B Narasimhan, Co-Is     09/17–08/21

State Government

Iowa Economic Development Authority
“Development and manufacture of next-gen SARS-CoV-2 vaccine”
B Narasimhan, PI     10/20–12/20

Iowa Regents Innovation Fund
“Development of flexible electronics fabrication platform”
M Uz, PI; S Mallapragada, Co-I     07/20–05/21

Foundations, Associations

Howard Hughes Medical Institute
“Integrated Education and Research Program in Nanomedicine”
S Mallapragada, PI     01/18–12/20

Companies

Merck & Company, Inc.
“Pulsatile release of multiple vaccine payloads from polyanhydride nanoparticles”
B Narasimhan, PI; M Wannemuehler, Co-I     02/19–05/21

Recently Completed Awards (ended within last three years)

National Institutes of Health

“Determining the role of Interleukin-17 in the immune response to respiratory syncytial virus infection”
J McGill, PI     01/19–04/20

“Exosomes and Neuroinflammation in Parkinson’s Disease”
A Kanthasamy, PI; AG Kanthasamy, Co-I     02/15–11/19

“Enhanced Shelf-life Nanovaccine Formulation for Immunity to Biodefense Pathogens”
B Narasimhan, PI; M Wannemuehler, B Bellaire, J Hostetter, T Dubensky, Co-Is     09/14–08/19

“Role of Mitochondria-Targeted CYP2D6 in Chemical Toxicity”
AG Kanthasamy, Co-I     02/15–12/18

“Highly Simplified Model of a Mammalian Intestinal Community”
G Phillips, PI; J Hostetter, A Jergens, M Wannemuehler, Co-Is     12/12–11/17

“Function and Inhibition of Multidrug Efflux Systems in Campylobacter”
Q Zhang, PI; E Yu, Co-I     12/15–11/17

National Science Foundation

“On-chip studies of neuron cells under magnetic field stimulation”
Q Long, PI; D Jiles, I Schneider, Co-Is    06/16–05/20

“Planning Grant: Engineering Research Center for Aging-centric Engineering Technologies (AgETech)”
B Narasimhan, PI; R Jain, T Lockhart, J Margrett, C Hertzog, Co-Is     09/19–08/19

U.S. Department of Agriculture

“Optimization and testing of a universal influenza vaccine for swine”
D Verhoeven, PI     06/17–05/20

“Next Generation Polyanhydride Nanovaccine Platform Technology for Poultry”
A Talaat, PI; B Narasimhan, Co-I     01/16–03/19

“Nanoparticle Delivery of Antibiotics for Disease Control in Cultured Shrimp”
L Bartholomay, PI; B Narasimhan and B Bellaire, Co-PIs     03/15–03/18

Foundations, Associations

PhRMA Foundation
“Develop Oral Vaccines with Miniguts”
Q Wang, PI     07/17–06/18

Crohns and Colitis Foundation
“Targeted Delivery of Intestinal Stem Cells to Treat Inflammatory Bowel Disease”
Q Wang, PI     07/15–06/18

Iowa Veterinary Medical Association
“Rapid Evaluation for Efficacy of Vaccines for Mycobacterium Avium SS Paratuberculosis in Cattle”
J Hostetter, PI; D Jones, Co-I     01/17–12/17

National Pork Board
“Efficacy of a Novel Intramammary Vaccine Delivery System for PEDV to Decrease Pre-weaning Mortality and Enhance Mechanisms of Immunity”
B Arruda, PI; P Arruda, D Jones, B Narasimhan, K Schwartz, J Zhang, Co-Is     12/16–12/17

Companies

AraVasc, Inc.
“Synthesis, characterization, and intracellular trafficking of pentablock copolymers”
S Mallapragada, PI     12/19–11/20

Imbed Biosciences, Inc.
“Nanomedicines to treat respiratory infections”
B Narasimhan, PI; D Verhoeven, M Wannemuehler, Co-Is     05/20–10/20

Triton Systems Inc.
“A Long-Term Anti-Malarial Drug-Releasing Implant”
B Narasimhan, PI     02/19–07/19

Merck & Company Inc.
“Investigation of a Candidate Universal Influenza Vaccine Targeting the HA Head”
D Verhoeven, PI; B Lee, B Sponseller, Co-Is     10/16–10/18

Merck & Company Inc.
“Investigation of Antibiotic-Resistant S. Pneumoniae Pathogenesis in a Unique Co-Infection Model”
D Verhoeven, PI; B Lee, M Ackermann, E Yu, Co-Is     11/16–10/18

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