“Type and depth of mucosal immunity in the airways induced by intranasal vaccines is dictated by the nature of polymer used in nanovaccines: studies in a pig model”
Different biodegradable polymer-derived nanoparticle- based intranasal and oral vaccines delivery platforms against viral and bacterial infections in food animals elicit various types and depth of immune responses. We studied the performance of nanovaccines made using chitosan, polyanhydride, poly lactic-co-glycolic acid, glycoconjugate, and liposomes in food animals. Our studies revealed the need for careful selection of an ideal polymer to prepare an effective nanovaccine, which depends on the nature of the pathogen and the type of immune response required for maximum efficacy and protection.
Renukaradhya Gourapura DVM, PhD
Professor, Center for Food Animal Health
The Ohio State University
Thursday, January 27, 3:00–4:00 PM CT
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