Publications

Our consortium members have a long history of collaboration on interdisciplinary research. Here is a partial list of journal articles and book chapters we have co-authored since 2015. Nanovaccine Institute researchers are shown in bold.

Respiratory infections

Darling R, Senapati S, Kelly SM, Kohut M, Narasimhan B, Wannemuehler M. STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice. Vaccine. 37(20): 2721-2730 (2019)

Ross K, Senapati S, Alley J, Darling R, Goodman J, Jefferson M, Uz M, Guo B, Yoon KJ, Verhoeven D, Kohut M, Mallapragada S, Wannemuehler M, Narasimhan B. Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice. Biomater Sci. Jan 21 (2019)

 Zacharias ZR, Ross KA, Hornick EE, Goodman JT, Narasimhan B, Waldschmidt TJ, Legge KL. Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections. Front Immunol. Aug 28;9:1953 (2018)

Renu S, Dhakal S, Kim E, Goodman J, Lakshmanappa YS, Wannemuehler MJ, Narasimhan B, Boyaka PN, Renukaradhya GJ. Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine. Cell Immunol. Jul;329:27-30 (2018)

Wagner-Muñiz DA, Haughney SL, Kelly SM, Wannemuehler MJ, Narasimhan B. Room Temperature Stable PspA-Based Nanovaccine Induces Protective Immunity. Front Immunol. Mar 2;9:325 (2018)

KA Ross, JR Adams, H Loyd, S Ahmed, A Sambol, SR Broderick, K Rajan, M Kohut, T Bronich, MJ Wannemuehler, S Carpenter, SK Mallapragada, B Narasimhan. Combination nanovaccine demonstrates synergistic enhancement in efficacy against influenza. ACS Biomater Sci Eng, 10:1021 (2016)

JE Vela Ramirez, L Tygrett, J Hao, H Habte, M Cho, N Greenspan, T Waldschmidt, B Narasimhan. Polyanhydride nanovaccines induce germinal center B cell formation and sustained serum antibody responses. J Biomed Nanotechnol., 12(6): 1303-11 (2016)

Renukaradhya, G.J., B. Narasimhan, S.K. Mallapragada. Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation, Journal of Control Release, 219:622-631 (2015)

KA Ross, H Loyd, W Wu, LM Huntimer, S Ahmed, A Sambol, Z Flickinger, SR Broderick, K Rajan, T Bronich, SK Mallapragada, MJ Wannemuehler, S Carpenter, and B Narasimhan. Polyanhydride-based H5 hemagglutinin influenza nanovaccines elicit protective virus neutralizing titers and cell-mediated immunity. Int J Nanomed, 10:229-243 (2015)

TM Brenza, LK Petersen, Y Zhang, LM Huntimer, AE Ramer-Tait, JM Hostetter, MJ Wannemuehler, and B Narasimhan. Pulmonary biodistribution and cellular uptake of intranasally administered monodisperse particles. Pharm Res, 32:1368-82. (2015)

Ross, KA., Loyd, H., Wu, W., Huntimer, LM., Ahmed, S., Sambol, A., Flickinger, Z., Broderick, SR., Rajan, K., Bronich, T., Mallapragada, SK., Wannemuehler, MJ., Carpenter, S., and Narasimhan, B., Polyanhydride-based H5 hemagglutinin influenza nanovaccines elicit protective virus neutralizing titers and cell-mediated immunity, Int J Nanomed 10, 229-243 (2015)

Neural disorders

Uz., M. Donta, M., Mededovic, M., Sakaguchi, D., and Mallapragada, S.K., “Development of Gelatin and Graphene-Based Nerve Regeneration Conduits Using 3D Printing Strategies for Electrical Transdifferentiation of Mesenchymal Stem Cells”, I&EC Res. (2019)

Poovaiah N, Davoudi Z, Peng H, Schlichtmann B, Mallapragada S, Narasimhan B, Wang Q. Treatment of neurodegenerative disorders through the blood-brain barrier using nanocarriers. Nanoscale. Sep 20;10(36):16962-16983 (2018)

Uz, M., Das, S., Sakaguchi, D.S., Mallapragada, S.K. and Claussen, J.C., “Advances in Controlling Differentiation of Adult Stem Cells for Peripheral Nerve Regeneration”, Adv. Healthcare Mater. Invited article, 1701046 (2018)

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD.  Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A. Nov;106(11):2881-2890 (2018)

Mullis AS, Schlichtmann BW, Narasimhan B, Cademartiri R, Mallapragada SK. Ligand-cascading nano-delivery devices to enable multiscale targeting of anti-neurodegenerative therapeutics. Biomed Mater. Feb 21;13(3):034102 (2018)

Ay M, Luo J, Langley M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson’s Disease. J Neurochem. Jun;141(5):766-782 (2017)

Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxid Redox Signal. Nov 10;27(14):1048-1066 (2017)

Uz, M., Buyukoz, M., Sharma, A., Sakaguchi, D., Altinkaya, S., and Mallapragada, S.K., Gelatin-based 3D conduits for transdifferentiation of mesenchymal stem cells into Schwann cell-like phenotypes. Acta Biomater. Apr 15;53:293-306 (2017)

Uz, M., Sharma, A., Adhikari, P., Sakaguchi, D., and Mallapragada, S.K., Development of Multifunctional Films for Peripheral Nerve Regeneration Conduits, Acta Biomat. 20 Jul 1;56:141-152 (2017)

Das, S., Uz, M., Ding, S., Lentner, M., Hondred, J., Cargill, A., Sakaguchi, D.S., Mallapragada, S., and Claussen, J., “Electrical Differentiation of Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes using Inkjet Printed Graphene Circuits”, Adv. Healthcare Mater., 6(7), 1601087 (2017)

Kondru N, Manne S, Greenlee J, Greenlee H, Anantharam V, Halbur P, Kanthasamy A, Kanthasamy AG. Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases. Sci Rep. Feb 24;7:43155 (2017).

De la Rosa, B., Sharma, A.D., Mallapragada, S.K., and Sakaguchi, D.S., “Transdifferentiation of BDNF-Hypersecreting Mesenchymal Stem Cells Significantly Enhances BNDF Secretion and Schwann Cell Marker Proteins”, J. Biosci. Bioeng., 124, 572-582 (2017)

Sharma, A.D., Horning, J., Uz, M., Cibrowski, P., Mallapragada, S.K., Gendelman, H., and Sakaguchi, D.S., “Proteomic Analysis of Mesenchymal Stem Cell Differentiation”, J. Proteomics, 165, 93-101 (2017)

Sharma, A., Zbarska, S., Petersen, E., Marti, M., Mallapragada, S.K., and Sakaguchi, D.S., Oriented Growth and Transdifferentiation of Mesenchymal Stem Cells Towards a Schwann Cell Fate on Micropatterned Substrates, J. Biosci. Bioeng., 121, 325-335 (2016)

Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou Q-Y, Kanthasamy AG, Kanthasamy A (2016) Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nat. Commun. 7:12932.

Rokad D, Ghaisas S, Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.  Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation. Brain Res Bull. 2016 Dec 16.

Brenza TM, Ghaisas S, Ramirez JE, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B (2016) Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy. Nanomedicine. 2017 Apr;13(3):809-820.

Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG.  Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease. J Neuroimmune Pharmacol. 2016 Jun;11(2):259-78.

Kim DS, Jin H, Anantharam V, Gordon R, Kanthasamy A, Kanthasamy AG. P73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity.  Neurotoxicology. 2016 Apr 20.

Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A.  Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson’s disease. Neurobiol Dis. 2016 May 2.

H Jin, A Kanthasamy, DS Harischandra, V Anantharam, A Rana, AG Kanthasamy. Targeted toxicants to dopaminergic neuronal cell death. Methods Mol Biol. 2015;1254:239-52.

DS Harischandra, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy. α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson’s disease. Toxicol Sci. 143(2):454-68 (2015)

A Charli, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy (2015 Jul 2). Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model. Neurotoxicology.

N Panicker, H Saminathan, H Jin, M Neal, DS Harischandra, R Gordon, K Kanthasamy, V Lawana, S Sarkar, J Luo, V Anantharam, AG Kanthasamy, A Kanthasamy. Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson’s disease. J Neurosci. 35(27) (2015)

M Ay, H Jin, DS Harischandra, A Asaithambi, A Kanthasamy, V Anantharam, AG Kanthasamy. Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson’s disease. J Neurochem. 2015 Oct;135(2):402-15.

A Sharma, S Zbarska, E Petersen, M Marti, SK Mallapragada, DS Sakaguchi. Oriented growth and transdifferentiation of mesenchymal stem cells towards a Schwann cell fate on micropatterned substrates. J Biosci Bioeng., 121, 325-335 (2016)

SK Mallapragada, TM Brenza, J McMillan, B Narasimhan, DS Sakaguchi, AD Sharma, S Zbarska, H Gendelman. Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicine. Nanomed Nanotechnol Biol Med. 11:715-725 (2015)

HE Gendelman, V Anantharam, T Bronich, S Ghaisas, H Jin, AG Kanthasamy, X Liu, J McMillan, RL Mosley, B Narasimhan, and SK Mallapragada. Nanoneuromedicines for degenerative, inflammatory, and infectious diseases of the nervous system. Nanomedicine. 2015 Apr;11(3):751-67. (2015)

Sharma, A.D., Brodskiy, P., Peterson, E., Dagdeviren, M., Ye, E.-A., Mallapragada, S.K., and Sakaguchi, D. High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies, Journal of Visualized Experiments, 95 (2015)

SK Mallapragada, TM Brenza, JM McMillan, B Narasimhan, DS Sakaguchi, AD Sharma, S Zbarska, and HE Gendelman, Enabling nanomaterial, nanofabrication, and cellular technologies for nanoneuromedicines,  Nanomedicine: Nanotechnol Biol Med Apr;11(3):715-29 (2015)

HE Gendelman, V Anantharam, T Brinich, S Ghaisas, H Jin, AG Kanthasamy, X Liu, J McMillan, RL Mosley, B Narasimhan, and SK Mallapragada, Nanomedicines for degenerative, inflammatory, and infectious diseases of the nervous system, Nanomedicine: Nanotechnol Biol Med 11, 751-767 (2015)

AD Sharma, PA Brodski, EM Petersen, M Dagdeviren, E Ye, SK Mallapragada, DS Sakaguchi, High throughput characterization of adult stem cells engineered for delivery of therapeutic factors for neuroprotective strategies, J. Vis. Exp. (95), e52242, (2015)

Tropical diseases

Rintelmann CL, Grinnage-Pulley T, Ross K, Kabotso DEK, Toepp A, Cowell A, Petersen CA, Narasimhan B,  Pohl N. Design and synthesis of multivalent α-1, 2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection. Beilstein Journal of Organic Chemistry 15, no. 1 (2019): 623-632

Lueth P, Haughney SL, Binnebose AM, Mullis AS, Peroutka-Bigus N, Narasimhan B, Bellaire BH. Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections. J Control Release. 2019 Jan 28;294:288-297.

Schaut R, Lamb I, Toepp A, Scott B, Mendes-Aguiar C, Coutinho J, Jerônimo SMB Wilson M, Harty J, Waldschmidt T, Petersen CA. Regulatory IgD^hi B cells suppress T cell function via IL-10 and PD-L1 during Visceral Leishmaniasis. J Immunol. 1502678. [Epub ahead of print], 2016

AM Binnebose, SL Haughney, RL Martin, P Imerman, B Narasimhan, BH Bellaire, Polyanhydride nanoparticle delivery platform dramatically enhances killing of filarial worms, PLoS Neglect Trop Dis, 9(10), e0004173. (2015).

Paquette C, Phanse Y, Perry J, Sanchez-Vargas I, Airs PM, Dunphy BM, Xu J, Carlson J, Luft C, DeSimone JM, Bartholomay LC & Beaty B. 2015. Biodistribution and trafficking of hydrogel nanoparticles in adult mosquitoes. Accepted PLoS Neglected Tropical Diseases

Phanse Y, Dunphy BM, Perry J, Airs PM, Xu J, Paquette C, Carlson J, Luft C, Beaty B, DeSimone JM & Bartholomay LC. 2015. Biodistribution and toxicity studies of PRINT hydrogel nanoparticles in mosquito larvae and cells. Accepted. PLoS Neglected Tropical Diseases

Roychoudhury, R., Martinez P. A., Grinnage-Pulley T., Schaut, R.G., Petersen, C.A., and Pohl, N.L.B. “Acid triggered degradable reagents for recognition of T cell responses to Leishmania- associated sugars,” Angew Chem Int Ed Engl. 10.1002/anie.201502807.

Cancer

M Uz, M Kalaga, R Pothuraju, J Ju, WM Junker, SK Batra, S Mallapragada, S Rachagani. Dual delivery nanoscale device for miR0345 and gemcitabine co-delivery to treat pancreatic cancer. J Control Release. Jan 28; 294:237-246. (2019)

R Bhatia, SK Gautam, A Cannon, C Thompson, BR Hall, A Aithal, K Banerjee, M Jain, JC Solheim, S Kumar, SK Batra. Cancer-associated mucins: role in immune modulation and metastasis. Cancer Metastasis Rev. 2019 Jan 8.

Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B, Salem AK. Single dose of polyanhydride particle-based vaccine generates potent antigen-specific antitumor immune responses. J Pharmacol Exp Ther. 370(3) 855-63 (2019)

Banerjee K, Kumar S, Ross KA, Gautam S, Poelaert B, Nasser MW, Aithal A, Bhatia R, Wannemuehler MJ, Narasimhan B, Solheim JC, Batra SK, Jain M. Emerging trends in the immunotherapy of pancreatic cancer. Cancer Lett. Mar 28;417:35-46 (2018)

Cannon A, Thompson C, Hall BR, Jain M, Kumar S, Batra SK. Desmoplasia in pancreatic ductal adenocarcinoma: insight into pathological function and therapeutic potential. Genes Cancer. 9(3-4):78-86 (2018)

A Aithal, S Fauth, P Kshirsagar, A Shah, I Lakshmanan, WM Junker, M Jain, MP Ponnusamy, SK Batra. MUC16 as a novel target for cancer therapy. Expert Opin Ther Targets. Aug; 22(8): 675-686 (2018)

Aithal A, Junker WM, Kshirsagar P, Das S, Kaur S, Orzechowski C, Gautam SK, Jahan R, Sheinin YM, Lakshmanan I, Ponnusamy MP, Batra SK, Jain M. Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer. PLoS One. 13(4):e0193907 (2018)

Gautam SK, Kumar S, Cannon A, Hall B, Bhatia R, Nasser MW, Mahapatra S, Batra SK, Jain M. MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma. Expert Opin Ther Targets. 21(7):657-669. (2017)

Seshacharyulu P, Baine MJ, Souchek JJ, Menning M, Kaur S, Yan Y, Ouellette MM, Jain M, Lin C, Batra SK. Biological determinants of radioresistance and their remediation in pancreatic cancer. Biochim Biophys Acta Rev Cancer. 1868(1):69-92.  (2017)

E Wafa, SM Geary, JT Goodman, B Narasimhan, AK Salem. The effect of polyanhydride chemistry in particle-based cancer vaccines on the magnitude of the anti-tumor immune response.  Acta Biomater (Epub Jan 4, 2017)

Kumar S, Cruz E, Joshi S, Patel A, Jahan R, Batra SK, Jain M. Genetic variants of mucins: unexplored conundrum. Carcinogenesis. 38(7):671-679. (2016)

Wang Y, Kumar S, Rachagani S, Sajja BR, Xie Y, Hang Y, Jain M, Li J, Boska MD, Batra SK, Oupický D. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials. 101:108-120. (2016)

Kaur S, Smith LM, Patel A, Menning M, Watley DC, Malik SS, Krishn SR, Mallya K, Aithal A, Sasson AR, Johansson SL, Jain M, Singh S, Guha S, Are C, Raimondo M, Hollingsworth MA, Brand RE, Batra SK. A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study. Am J Gastroenterol. 112(1):172-183. (2016)

Nanoparticles

Aging