Our consortium members have a long history of collaboration on interdisciplinary research. Here is a partial list of journal articles and book chapters we have co-authored since 2009. Nanovaccine Institute researchers are shown in bold.
Respiratory infections
Darling R, Senapati S, Kelly SM, Kohut M, Narasimhan B, Wannemuehler M. STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice. Vaccine. 37(20): 2721-2730 (2019)
Ross K, Senapati S, Alley J, Darling R, Goodman J, Jefferson M, Uz M, Guo B, Yoon KJ, Verhoeven D, Kohut M, Mallapragada S, Wannemuehler M, Narasimhan B. Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice. Biomater Sci. Jan 21 (2019)
Zacharias ZR, Ross KA, Hornick EE, Goodman JT, Narasimhan B, Waldschmidt TJ, Legge KL. Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections. Front Immunol. Aug 28;9:1953 (2018)
Renu S, Dhakal S, Kim E, Goodman J, Lakshmanappa YS, Wannemuehler MJ, Narasimhan B, Boyaka PN, Renukaradhya GJ. Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine. Cell Immunol. Jul;329:27-30 (2018)
Wagner-Muñiz DA, Haughney SL, Kelly SM, Wannemuehler MJ, Narasimhan B. Room Temperature Stable PspA-Based Nanovaccine Induces Protective Immunity. Front Immunol. Mar 2;9:325 (2018)
KA Ross, JR Adams, H Loyd, S Ahmed, A Sambol, SR Broderick, K Rajan, M Kohut, T Bronich, MJ Wannemuehler, S Carpenter, SK Mallapragada, B Narasimhan. Combination nanovaccine demonstrates synergistic enhancement in efficacy against influenza. ACS Biomater Sci Eng, 10:1021 (2016)
JE Vela Ramirez, L Tygrett, J Hao, H Habte, M Cho, N Greenspan, T Waldschmidt, B Narasimhan. Polyanhydride nanovaccines induce germinal center B cell formation and sustained serum antibody responses. J Biomed Nanotechnol., 12(6): 1303-11 (2016)
Renukaradhya, G.J., B. Narasimhan, S.K. Mallapragada. Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation, Journal of Control Release, 219:622-631 (2015)
KA Ross, H Loyd, W Wu, LM Huntimer, S Ahmed, A Sambol, Z Flickinger, SR Broderick, K Rajan, T Bronich, SK Mallapragada, MJ Wannemuehler, S Carpenter, and B Narasimhan. Polyanhydride-based H5 hemagglutinin influenza nanovaccines elicit protective virus neutralizing titers and cell-mediated immunity. Int J Nanomed, 10:229-243 (2015)
TM Brenza, LK Petersen, Y Zhang, LM Huntimer, AE Ramer-Tait, JM Hostetter, MJ Wannemuehler, and B Narasimhan. Pulmonary biodistribution and cellular uptake of intranasally administered monodisperse particles. Pharm Res, 32:1368-82. (2015)
Ross, KA., Loyd, H., Wu, W., Huntimer, LM., Ahmed, S., Sambol, A., Flickinger, Z., Broderick, SR., Rajan, K., Bronich, T., Mallapragada, SK., Wannemuehler, MJ., Carpenter, S., and Narasimhan, B., Polyanhydride-based H5 hemagglutinin influenza nanovaccines elicit protective virus neutralizing titers and cell-mediated immunity, Int J Nanomed 10, 229-243 (2015)
KA Ross, W Wu, H Loyd, L Huntimer, MJ Wannemuehler, S Carpenter, and B Narasimhan, Structural and antigenic stability of H5N1 hemagglutinin trimer upon release from polyanhydride nanoparticles, J Biomed Mater Res A 102, 4161-4168 (2014)
Ross, K., Lloyd, H., Wu, W., Huntimer, L., Ahmed, S., Sambol, A., Broderick, S., Flickinger, Z., Rajan, K., Hinrichs, S., Bronich, T., Mallapragada, S.K., Wannemuehler, M., Carpenter, S., and Narasimhan, B., Hemagglutinin-based Polyanhydride Nanovaccines Against H5N1 Influenza Elicit Protective Virus Neutralizing Titers and Cell-Mediated Immunity, Int J Nanomed, 10, 229-243 (2014).
KA Ross, LM Huntimer, JE Vela-Ramirez, JR Adams, SL Carpenter, ML Kohut, T Bronich, R Webby, KL Legge, SK Mallapragada, MJ Wannemuehler, and B Narasimhan, Vaccine technologies against avian influenza: current approaches and new directions. Journal of biomedical nanotechnology 10(9):2261-94 (2014)
KA Ross, SL Haughney, LK Petersen, P Boggiato, MJ Wannemuehler, and B Narasimhan, Lung deposition and cellular uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours, Adv Healthcare Mater, 3, 1071–1077 (2014)
KA Ross, W Wu, H Loyd, L Huntimer, S Carpenter, MJ Wannemuehler, and B Narasimhan, Structural stability and antigenicity of H5N1 hemagglutinin trimer upon release from polyanhydride nanoparticles, J Biomed Mater Res Part A: 102A: 4161–4168 (2014)
Boyden AW, Frickman AM, Legge KL, Waldschmidt TJ. Primary and long-term B-cell responses in the upper airway and lung after influenza A virus infection. Immunol Res. 59(1-3):73-80. (2014)
Legge KL, Waldschmidt TJ. Alcohol and the adaptive immune response in the airway: dendritic cell and lymphocyte impairments. In: Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach. ed David Guidot and Ashish J. Mehta. Springer Press. In Press, 2014.
Hemann EA, McGill JL, Legge KL. Chronic ethanol exposure selectively inhibits the influenza-specific CD8 T cell response during influenza a virus infection. Alcohol Clin Exp Res. 38(9):2403-13. (2014)
Y Phanse, B Carrillo-Conde, AE Ramer-Tait, SR Broderick, CS Kong, K Rajan, R Flick, R Mandell, BH Bellaire, MJ Wannemuehler, and B Narasimhan, A systems approach to designing next generation vaccines: combining amphiphilic nanoparticle platforms with α-galactose modified antigens, Sci Reports 4, 3775 (2014)
SL Haughney, P Lueth, D Wagner, TW Dubensky, BH Bellaire, B Narasimhan, and MJ Wannemuehler, Polyanhydride nanovaccine and cyclic dinucleotide based formulations stimulate innate immunity and modulate immune response, Trans Soc Biomater, 37, 124 (2014)
KA Ross, H Loyd, W Wy, LM Huntimer, S Ahmed, A Sambol, Z Flickinger, S Hinrichs, T Bronich, SK Mallpragada, MJ Wannemuehler, SL Carpenter, and B Narasimhan, Polyanhydride nanovaccines elicit protective virus neutralizing titers and cell-mediated immunity against influenza, Trans Soc Biomater, 37, 538 (2014)
T Brenza, MJ Wannemuehler, and B Narasimhan, Size and chemistry affect cellular distribution after intranasal administration of nanoparticles, Trans Soc Biomater, 37, 700 (2014)
SL Haughney, LK Petersen, AE Ramer-Tait, J King, A Schoofs, D Briles, MJ Wannemuehler, and B Narasimhan, Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles, Acta Biomater, 9(9), 8262-8271 (2013)
Y Phanse, LK Petersen, SL Haughney, AE Ramer-Tait, JM Hostetter, B Narasimhan, and MJ Wannemuehler, Single dose polyanhydride nanoparticle-based vaccine safely induces both cellular and humoral immunity, Trans Soc Biomater, 36, 356 (2013)
L Huntimer, AE Ramer-Tait, LK Petersen, KA Ross, KA Walz, C Wang, JM Hostetter, MJ Wannemuehler, and B Narasimhan, Polyanhydride nanoparticle-based influenza vaccine elicits viral neutralizing titers and enhances cell-mediated immunity, Trans Soc Biomater, 36 (2013)
KA Ross, SL Haughney, TM Brenza, L Huntimer, P Boggiato, MJ Wannemuehler, and B Narasimhan, Deposition and persistence of polyanhydride nanoparticle vaccines upon intranasal administration, Trans Soc Biomater, 36 (2013)
TM Brenza, LK Petersen, Y Zhang, L Huntimer, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Biodistribution and trafficking of intranasally administered monodisperse biodegradable particles, J Aerosol Med Pulmon Drug Del, 26(2), A30 (2013)
AM Parker, R Vardavas, CG Marcum, CA Gidengil, Conscious consideration of herd immunity in influenza vaccination decisions, Am J Prev Med, 45(1):118-21, 2013.
R Vardavas, CS Marcum. Modeling influenza vaccination behaviour via inductive reasoning games. In: Modeling the Interplay between Human Behavior and the Spread of Infectious Diseases. ed. P Manfredi and A d’Onofrio. Springer New York, 2013.
Warren K, Thompson N, Wannemuehler M, Kohut M. Antibody and CD8+ T cell memory response to influenza A/PR/8/34 infection is reduced in treadmill-exercised mice, yet still protective. Journal of applied physiology 114(10):1413-20 (2013)
Boyden AW, Legge KL, Waldschmidt TJ. Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses. PLoS One 7(7):e40733 (2012)
AV Chavez-Santoscoy, LM Huntimer, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, “Harvesting alveolar macrophages and evaluating cellular activation induced by polyanhydride nanoparticles,” J Vis Exp, 64, e3883 (2012)
A Chavez-Santoscoy, R Roychoudhury, AE Ramer-Tait, NL Pohl, MJ Wannemuehler, and B Narasimhan, “Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using pathogen-like amphiphilic polyanhydride nanoparticles,” Biomaterials, 33, 4762-4772 (2012)
LK Petersen, Y Phanse, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, “Amphiphilic polyanhydride nanoparticles stabilize Bacillus anthracis protective antigen,” Mol Pharmaceutics, 9, 874-882 (2012)
Y Phanse, BR Carrillo-Conde, AE Ramer-Tait, R Roychoudhury, NLB Pohl, B Narasimhan, MJ Wannemuehler, and BH Bellaire, Carbohydrate modification of novel polyanhydride nanoparticle adjuvants to promote pathogen-mimicking characteristics, J Immunol, 188 (2012)
Alexander C-M, Tygrett LT, Boyden AW, Wolniak KL, Legge KL, Waldschmidt T. T regulatory cells participate in the control of germinal center reactions. Immunology, 133:452 (2011)
Fan J, Edsen-Moore MR, Turner LE, Cook RT, Legge KL, Waldschmidt TJ, Schlueter AJ. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res, 35: 47 (2011)
BD Ulery, LK Petersen, Y Phanse, C-S Kong, SR Broderick, D Kumar, AE Ramer-Tait, B Carrillo-Conde, BH Bellaire, K Rajan, MJ Wannemuehler, DW Metzger, and B Narasimhan, Rational design of “pathogen-mimicking” amphiphilic materials as nanoadjuvants, Sci Reports, 1, 198 (2011)
BD Ulery, D Kumar, AE Ramer-Tait, MJ Wannemuehler, DW Metzger, and B Narasimhan, Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases, PLoS One, 6(3), e17642 (2011)
AV Chavez-Santoscoy, BR Carrillo-Conde, E-H Song, Y Phanse, AE Ramer-Tait, NL Pohl, MJ Wannemuehler, BH Bellaire, and B Narasimhan, Targeted activation of antigen presenting cells with mannose-modified polyanhydride nanoparticles, Trans Soc Biomater, 34 (2011)
LK Petersen, Y Phanse, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Polyanhydride nanoparticle adjuvants for anthrax vaccine, Trans Soc Biomater, 34 (2011)
Case, A. J., McGill, J. L., Tygrett, L. T., Shirasawa, T., Spitz, D. R., Waldschmidt, T. J., Legge, K. L., Domann, F. E. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free radical biology & medicine, 50(3), 448-58.(2010)
R Vardavas, R Breban, and S Blower, A universal long-term flu vaccine may not prevent severe epidemics, BMC Res Notes, 3:92 (2010)
Case AJ, McGill JL, Tygrett LT, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE. Novel immunological roles for superoxide in T-cell selection and influenza susceptibility. Free Rad Biol Med, 50:448 (2010)
Langlois RA, Meyerholz DK, Coleman RA, Cook RT, Waldschmidt TJ, Legge KL. Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice. Alcoholism: Clin Exp Res, 34:1425 (2010)
B Carrillo-Conde, E Schiltz, J Yu, FC Minion, GJ Phillips, MJ Wannemuehler, and B Narasimhan, Encapsulation into amphiphilic polyanhydride microparticles stabilizes Yersinia pestis protein antigens, Acta Biomater, 6(8), 3110-3119 (2010)
BR Carrillo-Conde, AV Chavez-Santoscoy, E-H Song, NL Pohl, MJ Wannemuehler, and B Narasimhan, Targeting dendritic cells with functionalized polyanhydride nanoparticles, Polym Prepr, 240, 14 (2010)
Y Phanse, LK Petersen, AE Ramer-Tait, BH Bellaire, B Narasimhan, and MJ Wannemuehler, Polyanhydride nanoparticle adjuvants for development of a single dose anthrax vaccine, Trans Soc Biomater, 33 (2010)
BD Ulery, D Kumar, MJ Wannemuehler, DW Metzger, and B Narasimhan, Immunomodulatory nanoparticle vaccines to provide protection against plague, Trans Soc Biomater, 33 (2010)
McGill J, Meyerholz DK, Edsen-Moore M, Young B, Coleman RA, Schlueter AJ, Waldschmidt TJ, Cook RT, Legge KL. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. J Immunol, 182:7803 (2009)
Gurung P, Young BM, Coleman RA, Wiechert S, Turner LE, Ray NB, Waldschmidt TJ, Legge KL, Cook RT. Chronic ethanol induced inhibition of antigen-specific CD8, but not CD4 T cell responses following Listeria monocytogenes inoculation. J Leuk Biol 85:34 (2009)
BR Carrillo-Conde, MP Torres, E Schiltz, MJ Wannemuehler, and B Narasimhan, Amphiphilic polyanhydrides for stabilization of therapeutic proteins, Trans Soc Biomater, 32 (2009)
BD Ulery, JH Wilson-Welder, MJ Wannemuehler, DW Metzger, and B Narasimhan, Novel vaccine strategies against Y. pestis, Trans Soc Biomater, 32 (2009)
Neural disorders
Uz., M. Donta, M., Mededovic, M., Sakaguchi, D., and Mallapragada, S.K., “Development of Gelatin and Graphene-Based Nerve Regeneration Conduits Using 3D Printing Strategies for Electrical Transdifferentiation of Mesenchymal Stem Cells”, I&EC Res. (2019)
Poovaiah N, Davoudi Z, Peng H, Schlichtmann B, Mallapragada S, Narasimhan B, Wang Q. Treatment of neurodegenerative disorders through the blood-brain barrier using nanocarriers. Nanoscale. Sep 20;10(36):16962-16983 (2018)
Uz, M., Das, S., Sakaguchi, D.S., Mallapragada, S.K. and Claussen, J.C., “Advances in Controlling Differentiation of Adult Stem Cells for Peripheral Nerve Regeneration”, Adv. Healthcare Mater. Invited article, 1701046 (2018)
Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A. Nov;106(11):2881-2890 (2018)
Mullis AS, Schlichtmann BW, Narasimhan B, Cademartiri R, Mallapragada SK. Ligand-cascading nano-delivery devices to enable multiscale targeting of anti-neurodegenerative therapeutics. Biomed Mater. Feb 21;13(3):034102 (2018)
Ay M, Luo J, Langley M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson’s Disease. J Neurochem. Jun;141(5):766-782 (2017)
Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxid Redox Signal. Nov 10;27(14):1048-1066 (2017)
Uz, M., Buyukoz, M., Sharma, A., Sakaguchi, D., Altinkaya, S., and Mallapragada, S.K., Gelatin-based 3D conduits for transdifferentiation of mesenchymal stem cells into Schwann cell-like phenotypes. Acta Biomater. Apr 15;53:293-306 (2017)
Uz, M., Sharma, A., Adhikari, P., Sakaguchi, D., and Mallapragada, S.K., Development of Multifunctional Films for Peripheral Nerve Regeneration Conduits, Acta Biomat. 20 Jul 1;56:141-152 (2017)
Das, S., Uz, M., Ding, S., Lentner, M., Hondred, J., Cargill, A., Sakaguchi, D.S., Mallapragada, S., and Claussen, J., “Electrical Differentiation of Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes using Inkjet Printed Graphene Circuits”, Adv. Healthcare Mater., 6(7), 1601087 (2017)
Kondru N, Manne S, Greenlee J, Greenlee H, Anantharam V, Halbur P, Kanthasamy A, Kanthasamy AG. Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases. Sci Rep. Feb 24;7:43155 (2017).
De la Rosa, B., Sharma, A.D., Mallapragada, S.K., and Sakaguchi, D.S., “Transdifferentiation of BDNF-Hypersecreting Mesenchymal Stem Cells Significantly Enhances BNDF Secretion and Schwann Cell Marker Proteins”, J. Biosci. Bioeng., 124, 572-582 (2017)
Sharma, A.D., Horning, J., Uz, M., Cibrowski, P., Mallapragada, S.K., Gendelman, H., and Sakaguchi, D.S., “Proteomic Analysis of Mesenchymal Stem Cell Differentiation”, J. Proteomics, 165, 93-101 (2017)
Sharma, A., Zbarska, S., Petersen, E., Marti, M., Mallapragada, S.K., and Sakaguchi, D.S., Oriented Growth and Transdifferentiation of Mesenchymal Stem Cells Towards a Schwann Cell Fate on Micropatterned Substrates, J. Biosci. Bioeng., 121, 325-335 (2016)
Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou Q-Y, Kanthasamy AG, Kanthasamy A (2016) Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nat. Commun. 7:12932.
Rokad D, Ghaisas S, Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation. Brain Res Bull. 2016 Dec 16.
Brenza TM, Ghaisas S, Ramirez JE, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B (2016) Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy. Nanomedicine. 2017 Apr;13(3):809-820.
Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG. Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease. J Neuroimmune Pharmacol. 2016 Jun;11(2):259-78.
Kim DS, Jin H, Anantharam V, Gordon R, Kanthasamy A, Kanthasamy AG. P73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity. Neurotoxicology. 2016 Apr 20.
Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson’s disease. Neurobiol Dis. 2016 May 2.
H Jin, A Kanthasamy, DS Harischandra, V Anantharam, A Rana, AG Kanthasamy. Targeted toxicants to dopaminergic neuronal cell death. Methods Mol Biol. 2015;1254:239-52.
DS Harischandra, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy. α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson’s disease. Toxicol Sci. 143(2):454-68 (2015)
A Charli, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy (2015 Jul 2). Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model. Neurotoxicology.
N Panicker, H Saminathan, H Jin, M Neal, DS Harischandra, R Gordon, K Kanthasamy, V Lawana, S Sarkar, J Luo, V Anantharam, AG Kanthasamy, A Kanthasamy. Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson’s disease. J Neurosci. 35(27) (2015)
M Ay, H Jin, DS Harischandra, A Asaithambi, A Kanthasamy, V Anantharam, AG Kanthasamy. Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson’s disease. J Neurochem. 2015 Oct;135(2):402-15.
A Sharma, S Zbarska, E Petersen, M Marti, SK Mallapragada, DS Sakaguchi. Oriented growth and transdifferentiation of mesenchymal stem cells towards a Schwann cell fate on micropatterned substrates. J Biosci Bioeng., 121, 325-335 (2016)
SK Mallapragada, TM Brenza, J McMillan, B Narasimhan, DS Sakaguchi, AD Sharma, S Zbarska, H Gendelman. Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicine. Nanomed Nanotechnol Biol Med. 11:715-725 (2015)
HE Gendelman, V Anantharam, T Bronich, S Ghaisas, H Jin, AG Kanthasamy, X Liu, J McMillan, RL Mosley, B Narasimhan, and SK Mallapragada. Nanoneuromedicines for degenerative, inflammatory, and infectious diseases of the nervous system. Nanomedicine. 2015 Apr;11(3):751-67. (2015)
Sharma, A.D., Brodskiy, P., Peterson, E., Dagdeviren, M., Ye, E.-A., Mallapragada, S.K., and Sakaguchi, D. High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies, Journal of Visualized Experiments, 95 (2015)
SK Mallapragada, TM Brenza, JM McMillan, B Narasimhan, DS Sakaguchi, AD Sharma, S Zbarska, and HE Gendelman, Enabling nanomaterial, nanofabrication, and cellular technologies for nanoneuromedicines, Nanomedicine: Nanotechnol Biol Med Apr;11(3):715-29 (2015)
HE Gendelman, V Anantharam, T Brinich, S Ghaisas, H Jin, AG Kanthasamy, X Liu, J McMillan, RL Mosley, B Narasimhan, and SK Mallapragada, Nanomedicines for degenerative, inflammatory, and infectious diseases of the nervous system, Nanomedicine: Nanotechnol Biol Med 11, 751-767 (2015)
AD Sharma, PA Brodski, EM Petersen, M Dagdeviren, E Ye, SK Mallapragada, DS Sakaguchi, High throughput characterization of adult stem cells engineered for delivery of therapeutic factors for neuroprotective strategies, J. Vis. Exp. (95), e52242, (2015)
S.L. Solin, Y. Wang, J. Mauldin, L. Schultz, D.E. Lincow, P.A. Brodskiy, C.A. Jones, J. Syrkin-Nikolau, J.M. Linn, J.J. Essner, J.M. Hostetter, E.M. Whitley, J.D. Cameron, H-H. Chou, A.J. Severin, D.S. Sakaguchi, M. McGrail. Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis. PLoS ONE. 9(12): e114888 (2014)
M. Marti, A. Sharma, D.S. Sakaguchi, and S.K. Mallapragada (2013) Nanomaterials for Neural Tissue Engineering. In “Nanomaterials in Tissue Engineering: Characterization, Fabrication and Applications”, Gaharwar, Sant, Hancock and Harding (eds.). Harvard-MIT Division of Health Sciences, published by Woodhead Publishing-Cambridge.
M. Marti, D.S. Sakaguchi, and S.K. Mallapragada (2012) Neural tissue engineering strategies. In “Biomedical and Health Research Series, Regenerative Medicine and Cell Therapy” J.F. Stoltz (ed.). IOS Press-Amsterdam.
CL Howk, HA Levine, MW Smiley, SK Mallapragada, M Nilsen-Hamilton, and D Sakaguchi, A Mathematical Model for Selective Differentiation of Neural Progenitor Cells on Micropatterned Polymer Substrates, Math. Biosci., 238, 65-79 (2012)
LK Petersen, J Oh, DS Sakaguchi, SK Mallapragada, and B Narasimhan, Amphiphilic polyanhydride scaffolds promote neural stem cell growth and adhesion, Tissue Eng, 17, 2533-2541 (2011)
LK Petersen, J Oh, DS Sakaguchi, SK Mallapragada, and B Narasimhan, Amphiphilic polyanhydride films for tissue engineering, Trans Soc Biomater, 34 (2011)
Asaithambi A, Kanthasamy A, Saminathan H, Anantharam V, and Kanthasamy AG Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener 6:43 (2011)
Saminathan H, Asaithambi A, Anantharam V, Kanthasamy AG, and Kanthasamy A (2011) Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCdelta-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology 32:567-577.
Jin H, Kanthasamy A, Anantharam V, Rana A, and Kanthasamy AG Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. J Biol Chem 286: 19840-19859 (2011)
Ariza, C.A., McHugh, K.P., White, S.J., Sakaguchi, D.S.,and Mallapragada, S.K. Extracellular Matrix Proteins and Astrocyte-Derived Soluble Factors Influence the Differentiation and Proliferation of Adult Neural Progenitor Cells. Journal of Biomedical Materials Research A. 94(3): 816-824 (2010)
C.C. Blong, C.-J. Jeon, J.-Y. Yeo, E.-A. Ye, J. Oh, J.M. Callahan, W.D. Law, S. Mallapragada, and D.S. Sakaguchi. Differentiation and Behavior of Human Neural Progenitor Cells on Micropatterned Substrates and After Transplantation into the Developing Retina. Journal of Neuroscience Research. 88(7): 1445-56 (2010)
Ariza, C.A., Fluery, A.T., Toromos, C.J., Petruk, V., Chawla, S., Oh, J., Sakaguchi, D.S., and Mallapragada, S.K. Altered Neurogenesis, Alignment, and Viability: The influence of an Electric Field on Hippocampal Neural Progenitor Cells. Stem Cell Reviews and Reports. 6(4): 585-600 (2010)
Oh, J., Recknor, J.B., Recknor, J.C., Mallapragada, S.K., and Sakaguchi, D.S. (2009) Soluble factors from neocortical astrocytes enhance neuronal differentiation of neural progenitor cells from adult rat hippocampus on polymer substrates. Journal of Biomedical Materials Research A. 91(2): 575-85.
E. N. Boote Jones, D.S. Sakaguchi, and S.K. Mallapragada. (2009) Development and differentiation of neural stem and progenitor cells on synthetic and biological-based surfaces. In “Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses”, D.A. Puleo and R. Bizios (eds.) Springer Science/Business Media, LLC.
Tropical diseases
Rintelmann CL, Grinnage-Pulley T, Ross K, Kabotso DEK, Toepp A, Cowell A, Petersen CA, Narasimhan B, Pohl N. Design and synthesis of multivalent α-1, 2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection. Beilstein Journal of Organic Chemistry 15, no. 1 (2019): 623-632
Lueth P, Haughney SL, Binnebose AM, Mullis AS, Peroutka-Bigus N, Narasimhan B, Bellaire BH. Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections. J Control Release. 2019 Jan 28;294:288-297.
Schaut R, Lamb I, Toepp A, Scott B, Mendes-Aguiar C, Coutinho J, Jerônimo SMB Wilson M, Harty J, Waldschmidt T, Petersen CA. Regulatory IgDhi B cells suppress T cell function via IL-10 and PD-L1 during Visceral Leishmaniasis. J Immunol. 1502678. [Epub ahead of print], 2016
AM Binnebose, SL Haughney, RL Martin, P Imerman, B Narasimhan, BH Bellaire, Polyanhydride nanoparticle delivery platform dramatically enhances killing of filarial worms, PLoS Neglect Trop Dis, 9(10), e0004173. (2015).
Paquette C, Phanse Y, Perry J, Sanchez-Vargas I, Airs PM, Dunphy BM, Xu J, Carlson J, Luft C, DeSimone JM, Bartholomay LC & Beaty B. 2015. Biodistribution and trafficking of hydrogel nanoparticles in adult mosquitoes. Accepted PLoS Neglected Tropical Diseases
Phanse Y, Dunphy BM, Perry J, Airs PM, Xu J, Paquette C, Carlson J, Luft C, Beaty B, DeSimone JM & Bartholomay LC. 2015. Biodistribution and toxicity studies of PRINT hydrogel nanoparticles in mosquito larvae and cells. Accepted. PLoS Neglected Tropical Diseases
Choudhury, R., Martinez, P., Grinnage-Pulley, T., Schaut, R.G., Petersen, C., Pohl, N. “Synthesis of acid-labile linker for dendrimer Leishmania-associated cap carbohydrates and evaluation of adaptive immune responses to carbohydrates.” Angewandte Chemie, (submitted).
Roychoudhury, R., Martinez P. A., Grinnage-Pulley T., Schaut, R.G., Petersen, C.A., and Pohl, N.L.B. “Acid triggered degradable reagents for recognition of T cell responses to Leishmania- associated sugars,” Angew Chem Int Ed Engl. 10.1002/anie.201502807.
AM Binnebose, R Martin, SL Haughney, B Narasimhan, and BH Bellaire, “Polyanhydride nanoparticle delivery platform enables enhanced killing of filarial worms,” BMES Proceed, 2014
Gibson-Corley, K. N., Bockenstedt, M., Boggiatto, M.P., Petersen, C.A., Bellaire, B, Jones, D.E., (2014) “Fc Gamma Receptor Recognition is Necessary for Antibody-Enhanced Intracellular Killing of Leishmania amazonensis.” PLoS ONE., Sep 5;9(9):e106426.
Boggiatto, P., Martinez, P., Jones, D.E., Bellaire, B., Catling, A., Petersen, C.A., (2014) “MP1-mediated Endosomal Extracellular signal-related kinase (ERK) activation required for Leishmania amazonensis immune alteration” Microbes and Infection. Vol. 16, 328-336.
Boggiatto PM, Martinez PA, Pullikuth A, Jones DE, Bellaire B, Catling A, Petersen C. (2014). Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold. Microbes and infection, 16(4), 328-36.
KN Gibson-Corley, M Bockenstedt, PM Boggiatto, CA Petersen, B Bellaire, DE Jones, “Fc Gamma Receptor Recognition is Necessary for Antibody-Enhanced Intracellular Killing of Leishmania amazonensis.” PLoS ONE, Sep 5;9(9):e106426. (2014)
KN Gibson-Corley, M Bockenstedt, H Li, PM Boggiatto, Y Phanse, CA Petersen, B Bellaire, DE Jones, “An In Vitro Model of Antibody-Enhanced Killing of the Intracellular Parasite Leishmania amazonensis,” PLoS One. 2014 Sep 5;9(9):e106426.
Boggiatto, P., Martinez, P., Jones, D.E., Bellaire, B., Catling, A., Petersen, C.A. (2014) “MP1-mediated Endosomal Extracellular signal-related kinase (ERK) activation required for Leishmania amazonensis immune alteration” Microbes and Infection. (in press).
Esch KJ, Juelsgaard R, Martinez PA, Jones DE, Petersen CA. Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol. 191(11):5542-50.(2013)
Kauffman, L., Bjork, J.M., Boggiatto, M.P., Gallup, J., Bellaire, B., Petersen, C.A. (2013) “Early Detection of Brucella canis via Quantitative Polymerase Chain Reaction Analysis.” Zoonoses and Public Health, doi: 10.1111/zph.12041.
Y Phanse, P Lueth, AE Ramer-Tait, BR Carrillo-Conde, B Narasimhan, MJ Wannemuehler, and BH Bellaire, “Evaluating cellular interactions of polyanhydride particles for intracellular delivery of antibiotics”, Trans Soc Biomater, 36, 378 (2013)
Y Phanse, P Lueth, J Groen, J Ritchie, BR Carrillo-Conde, LK Petersen, P Imerman, B Narasimhan, and BH Bellaire, “Nanoparticle-based platform enables increased intracellular antibiotic delivery and killing of Brucella”, Trans Soc Biomater, 36 (2013)
Gibson-Corley, K. N., Boggiatto, M.P., Petersen, C.A., Waldschmidt, T.J, Jones, D.E. (2012) “B cell germinal center response but not IL-21 production leads to differential healing after Leishmania co-infection.” American Journal of Pathology, Vol. 180(5), 2009-17.
Osanya, A.; Song, E.-H.; Metz, K.; Shimak, R. M.; Boggiatto, P. M.; Huffman, E.; Johnson, C.; Hostetter, J. M.; Pohl, N. L. B.; Petersen, C. A. Pathogen-derived oligosaccharides improve innate immune response to intracellular parasite infection. Am. J. Pathol. 2011, 179, 1329-1337.
Boggiatto, M.P., Gibson-Corley, K. N., Metz, K., Gallup, J., Hostetter, J.M., Mullin, K., Petersen, C.A. (2011) “Vertical transmission of Leishmania infantum in naturally-infected Foxhounds in North America.” PLoS Negl. Trop.Dis. 5(4): e1019. doi:10.1371/journal.pntd.0001019.
Ramer-Tait, A.E., Petersen, C.A., Jones D.E.(2011)“IL-2 limits IL-12 enhanced lymphocyte proliferation during Leishmania amazonensis infection.” Cell. Immunol., doi:10.1016/j.cellimm.2011.03.016.
Song, E.-H.; Osanya, A. O.; Petersen, C. A.; Pohl, N. L. B. Synthesis of multivalent tuberculosis and Leishmania-associated capping carbohydrates reveals structure-dependent responses allowing immune evasion. J. Am. Chem. Soc. 2010, 132, 11428-11430.
Boggiatto, M.P., Ramer-Tait, A.E., Gallup, J., Gibson-Corley, K. N., Metz, K., Kramer, E. E., Hostetter, J.M., Jones, D.E., Petersen, C.A. (2010) “Immunologic indicators of clinical progression during canine Leishmania infantum infection.” Clin. Vacc. Immunol., Vol. 17(2) 267-73.
Gibson-Corley K.N., Boggiatto P.M., Petersen C.A., Jones D.E. (2010) Co-infection with Leishmania major and Leishmania amazonensis in Two Murine Models; a role for B cells in the Cell-Mediated Immune Response. International Journal of Parasitology, Vol. 40, 157-161.
Boggiatto, M. P., Gibson-Corley, K. N., Ghosh, M., Jie, F., Jones, D. E., Petersen, C. A. (2009) “Altered dendritic cell phenotype in response to Leishmania amazonensis is mediated by MAP kinase, ERK.” American Journal of Pathology, Vol. 174(5), 1818-1823.
Cancer
M Uz, M Kalaga, R Pothuraju, J Ju, WM Junker, SK Batra, S Mallapragada, S Rachagani. Dual delivery nanoscale device for miR0345 and gemcitabine co-delivery to treat pancreatic cancer. J Control Release. Jan 28; 294:237-246. (2019)
R Bhatia, SK Gautam, A Cannon, C Thompson, BR Hall, A Aithal, K Banerjee, M Jain, JC Solheim, S Kumar, SK Batra. Cancer-associated mucins: role in immune modulation and metastasis. Cancer Metastasis Rev. 2019 Jan 8.
Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B, Salem AK. Single dose of polyanhydride particle-based vaccine generates potent antigen-specific antitumor immune responses. J Pharmacol Exp Ther. 2018 Oct 25.
Banerjee K, Kumar S, Ross KA, Gautam S, Poelaert B, Nasser MW, Aithal A, Bhatia R, Wannemuehler MJ, Narasimhan B, Solheim JC, Batra SK, Jain M. Emerging trends in the immunotherapy of pancreatic cancer. Cancer Lett. Mar 28;417:35-46 (2018)
Cannon A, Thompson C, Hall BR, Jain M, Kumar S, Batra SK. Desmoplasia in pancreatic ductal adenocarcinoma: insight into pathological function and therapeutic potential. Genes Cancer. 9(3-4):78-86 (2018)
A Aithal, S Fauth, P Kshirsagar, A Shah, I Lakshmanan, WM Junker, M Jain, MP Ponnusamy, SK Batra. MUC16 as a novel target for cancer therapy. Expert Opin Ther Targets. Aug; 22(8): 675-686 (2018)
Aithal A, Junker WM, Kshirsagar P, Das S, Kaur S, Orzechowski C, Gautam SK, Jahan R, Sheinin YM, Lakshmanan I, Ponnusamy MP, Batra SK, Jain M. Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer. PLoS One. 13(4):e0193907 (2018)
Gautam SK, Kumar S, Cannon A, Hall B, Bhatia R, Nasser MW, Mahapatra S, Batra SK, Jain M. MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma. Expert Opin Ther Targets. 21(7):657-669. (2017)
Seshacharyulu P, Baine MJ, Souchek JJ, Menning M, Kaur S, Yan Y, Ouellette MM, Jain M, Lin C, Batra SK. Biological determinants of radioresistance and their remediation in pancreatic cancer. Biochim Biophys Acta Rev Cancer. 1868(1):69-92. (2017)
E Wafa, SM Geary, JT Goodman, B Narasimhan, AK Salem. The effect of polyanhydride chemistry in particle-based cancer vaccines on the magnitude of the anti-tumor immune response. Acta Biomater (Epub Jan 4, 2017)
Kumar S, Cruz E, Joshi S, Patel A, Jahan R, Batra SK, Jain M. Genetic variants of mucins: unexplored conundrum. Carcinogenesis. 38(7):671-679. (2016)
Wang Y, Kumar S, Rachagani S, Sajja BR, Xie Y, Hang Y, Jain M, Li J, Boska MD, Batra SK, Oupický D. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials. 101:108-120. (2016)
Kaur S, Smith LM, Patel A, Menning M, Watley DC, Malik SS, Krishn SR, Mallya K, Aithal A, Sasson AR, Johansson SL, Jain M, Singh S, Guha S, Are C, Raimondo M, Hollingsworth MA, Brand RE, Batra SK. A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study. Am J Gastroenterol. 112(1):172-183. (2016)
I Lakshmanan, MP Ponnusamy, MA Macha, D Haridas, PD Majhi, S Kaur, M Jain, SK Batra, AK Ganti. Mucins in lung cancer: diagnostic, prognostic and therapeutic implications. J Thorac Oncol. 10(1):19-27. (2015)
S Joshi, S Kumar, S Bafna, S Rachagani, KW Wagner, M Jain, SK Batra. Genetically engineered mucin mouse models for inflammation and cancer. Cancer Metas Rev. Dec;34(4):593-609 (2015)
MA Macha, SR Krishn, R Jahan, K Banerjee, SK Batra, M Jain. Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer. Cancer Treat Rev. 41(3):277-88 (2015)
AV Krasnoslobodtsev, MP Torres, S Kaur, IV Vlassiouk, RJ Lipert, M Jain, SK Batra, YL Lyubchenko. Nano-immunoassay with improved performance for detection of cancer biomarkers. Nanomedicine. 11(1):167-73 (2015)
LM Huntimer, KA Ross, RJ Darling, NE Winterwood, P Boggiato, B Narasimhan, AE Ramer-Tait, and MJ Wannemuehler, Polyanhydride nanovaccine platform enhances antigen-specific cytotoxic T cell responses, Technology 2(2), (2014)
VB Joshi, SM Geary, BR Carrillo-Conde, B Narasimhan, and AK Salem, Characterizing the anti-tumor response in mice treated with antigen-loaded polyanhydride microparticles, Acta Biomater, 9(3), 5583-5589 (2013)
R Darling, LM Huntimer, KA Ross, AE Ramer-Tait, B Narasimhan, and MJ Wannemuehler, Polyanhydride nanoparticle vaccine platform delays tumor growth, (2013)
LM Huntimer, KA Ross, R Darling, AE Ramer-Tait, B Narasimhan, and MJ Wannemuehler, Humoral immune responses elicited by the polyanhydride particle vaccine platform are facilitated by enhanced T follicular helper cell phenotype,
LM Huntimer, KA Ross, AE Ramer-Tait, B Narasimhan, and MJ Wannemuehler, Polyanhydride particle vaccine platform enhances early antigen-specific cytotoxic T cell responses, J Immunol, 190, 17918 (2013)
R Darling, L Huntimer, KA Ross, N Winterwood, B Narasimhan, AE Ramer-Tait, and MJ Wannemuehler, Polyanhydride nanoparticle vaccine platform delays tumor growth in an antigen specific model, Trans Soc Biomater, 36 (2013)
L Huntimer, KA Ross, R Darling, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Humoral responses elicited by polyanhydride nanoparticle formulations are facilitated by enhanced CD4+ T cell helper cells, Trans Soc Biomater, 36 (2013)
L Huntimer, KA Ross, R Darling, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Polyanhydride particle vaccine platform enhances antigen-specific cytotoxic T cell responses, Trans Soc Biomater, 36 (2013)
L Huntimer, KA Ross, LK Petersen, B Narasimhan, MJ Wannemuehler, and AE Ramer-Tait, “Antigen loaded polyanhydride particle vaccines expand CD8+ T cell responses at early time points, Trans Soc Biomater, 35 (2012)
Nanoparticles
Senapati, S., Darling, R.J, Loh, D., Schneider, I.C., Wannemuehler, M.J., Narasimhan, B. and Mallapragada, S.K., “Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery of Antigen and Improve Vaccine Efficacy While Inducing Low Inflammation”, ACS Biomat. Sci. Eng. (2019)
Carter P, Narasimhan B, Wang Q. Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases. Int J Pharm. Jan 30;555:49-62 (2019)
Brenza, T., Schlichtmann, B., Bhargavan, B., Vela Ramirez, J., Nelson, R., Panthani, M., McMillan, J., Kalyanaraman, B., Gendelman, H., Anantharam, V., Kanthasamy, A., Mallapragada, S.K., Narasimhan, B., and Kanmogne, G. “Biodegradable Polyanhydride-based Nanomedicines for Blood to Brain Drug Delivery”, J. Biomed. Mater. Res. A, (2019)
Wafa EI, Geary SM, Goodman JT, Narasimhan B, Salem AK. The effect of polyanhydride chemistry in particle-based cancer vaccines on the magnitude of the anti-tumor immune response. Acta biomaterialia, 50:417-427 (2017)
Phanse Y, Carrillo-Conde BR, Ramer-Tait AE, Roychoudhury R, Broderick S, Pohl N, Rajan K, Narasimhan B, Wannemuehler MJ, Bellaire BH. Functionalization promotes pathogen-mimicking characteristics of polyanhydride nanoparticle adjuvants. J Biomed Mater Res A., Oct;105(10):2762-2771 (2017)
B Narasimhan, JT Goodman, JE Vela Ramirez. Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery, Ann Rev Biomed Eng 18, 25-49 (2016)
Phanse Y, Lueth P, Ramer-Tait AE, Carrillo-Conde BR, Narasimhan B, Wannemuehler MJ, Bellaire BH. Cellular Internalization Mechanisms of Polyanhydride Particles: Implications for Rational Design of Drug Delivery Vehicles. J Biomed Nanotechnol, Jul;12(7):1544-52 (2016)
Vela-Ramirez JE, Tygrett LT, Hoa J, Habte HH, Cho MW, Greenspan NS, Waldschmidt TJ, Narasimhan B. Polyanhydride nanovaccines induce germinal center B cell formation and sustained serum antibody responses. J Biomed Nanotechnol. 12:1303, 2016.
Y Phanse, P Lueth, AE Ramer-Tait, BR Carrillo-Conde, MJ Wannemuehler, B Narasimhan, BH Bellaire. Cellular internalization mechanisms of polyanhydride particles: implications for rational design of drug delivery vehicles, J Biomed Nanotechnol, Jul;12(7):1544-52 (2016)
JE Vela-Ramirez, LT Tygrett, J Hao, HH Habte, MW Cho, NS Greenspan, TJ Waldschmidt, B Narasimhan. Polyanhydride Nanovaccines Induce Germinal Center B Cell Formation and Sustained Serum Antibody Responses. J Biomed Nanotechnol. Jun;12(6):1303-11 (2016)
KA Ross, TM Brenza, A Binnebose, Y Phanse, AG Kanthasamy, H Gendelman, AK Salem, LC Bartholomay, BH Bellaire, B Narasimhan. Nano-enabled delivery of diverse payloads across complex biological barriers. J Contr Rel. 219, 548-559 (2015).
F Jia, SK Mallapragada, B Narasimhan. Multi-enzyme immobilization and co-localization on nanoparticles enabled by DNA hybridization. Ind Eng Chem Res 54 (42), 10212-10220 (2015). Invited article.
H Peng, X Liu, G Wang, M Li, K Bratlie, E Cochran, Q Wang. Polymeric multifunctional nanomaterials for theranostics. J Mater Chem B. 3:6856-70 (2015)
JE Vela-Ramirez, JT Goodman, PM Boggiatto, R Roychoudhury, NLB Pohl, JM Hostetter, MJ Wannemuehler, B Narasimhan. Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. The AAPS J. 17(1):256-267 (2015)
BR Carrillo-Conde, RJ Darling, SJ Seiler, AE Ramer-Tait, MJ Wannemuehler, B Narasimhan. Sustained release and stabilization of therapeutic antibodies using amphiphilic polyanhydride nanoparticles. Chem Eng Sci. 125:98-107 (2015)
Brenza TM, Petersen LK, Zhang Y, Huntimer LM, Ramer-Tait AE, Hostetter JM, Wannemuehler MJ, Narasimhan B. Pulmonary biodistribution and cellular uptake of intranasally administered monodisperse particles. Pharm Res. 32:1368-82 (2015)
SK Mallapragada, TM Brenza, JEM McMillan, B Narasimhan, DS Sakaguchi, AD Sharma, S Zbarska, HE Gendelman Enabling Nanomaterial, Nanofabrication and Cellular Technologies for Nanoneuromedicines. Nanomedicine: Nanotechnol Biol Med. 11(3):715-729 (2015)
F Jia, SK Mallapragada, B Narasimhan. Multi-enzyme immobilization and co-localization on nanoparticles enabled by DNA hybridization, Ind Eng Chem Res, 54(28), 10212-10220 (2015)
Y Phanse, P Lueth, AE Ramer-Tait, BR Carrillo-Conde, MJ Wannemuehler, B Narasimhan, BH Bellaire. Cellular internalization mechanisms of polyanhydride particles: implications for rational design of drug delivery vehicles, J Biomed Nanotechnol Jul;12(7):1544-52, (2015)
JE Vela-Ramirez, JT Goodman, PM Boggiatto, R Roychoudhury, NLB Pohl, JM Hostetter, MJ Wannemuehler, B Narasimhan. Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles, The AAPS J 17(1), 256-267 (2015)
BR Carrillo-Conde, RJ Darling, SJ Seiler, AE Ramer-Tait, MJ Wannemuehler, B Narasimhan. Sustained release and stabilization of therapeutic antibodies using amphiphilic polyanhydride nanoparticles, Chem Eng Sci, 125, 98-107 (2015)
JT Goodman, JE Vela-Ramirez, R Roychoudhury, PM Boggiatto, NLB Pohl, MJ Wannemuehler, B Narasimhan. Nanoparticle chemistry and functionalization differentially regulates dendritic cell-nanoparticle interactions and triggers dendritic cell maturation, Particle & Particle Syst Charact 31(12), 1269-1280 (2014)
SL Haughney, KA Ross, PM Boggiatto, MJ Wannemuehler, B Narasimhan. Effect of nanovaccine chemistry on humoral immune response kinetics and maturation, Nanoscale 6(22), 13770-13778 (2014)
JE Vela-Ramirez, R Roychoudhury, HH Habte, MW Cho, NLB Pohl, B Narasimhan. Carbohydrate-functionalized nanovaccines preserve HIV antigen stability and activate antigen presenting cells, J Biomater Sci Polym Ed 25(13), 1387-1406 (2014)
J Adams, M Goswami, N Pohl, SK Mallapragada. Functionalization of Block Copolymers with Pathogen-Mimicking Sugars as Potential Vaccine Carriers, RSC Adv., 4, 15655-15663 (2014)
T Brenza, MJ Wannemuehler, B Narasimhan. Size and chemistry affect cellular distribution after intranasal administration of nanoparticles, Trans Soc Biomater, 37, 700 (2014)
SL Haughney, P Lueth, D Wagner, TW Dubensky, BH Bellaire, B Narasimhan, MJ Wannemuehler. Polyanhydride nanovaccine and cyclic dinucleotide based formulations stimulate innate immunity and modulate immune response, Trans Soc Biomater, 37, 124 (2014)
KA Ross, SL Haughney, LK Petersen, PM Boggiatto, MJ Wannemuehler, B Narasimhan. Deposition and uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours, Adv Healthcare Mater 3(7), 1071-1077 (2014)
LM Huntimer, KA Ross, RJ Darling, NE Winterwood, PM Boggiatto, B Narasimhan, AE Ramer-Tait, MJ Wannemuehler. Polyanhydride nanovaccine platform enhances antigen-specific cytotoxic T cell responses, Technology 2(2), 171-175 (2014)
JE Vela-Ramirez, R Roychoudhury, HH Habte, MW Cho, NLB Pohl, B Narasimhan. Carbohydrate-functionalized nanovaccines preserve HIV antigen stability and activate antigen presenting cells, J Biomater Sci Polym Ed 25(13), 1387-1406 (2014)
J Adams, SK Mallapragada. Enhancing the Immune Response Through Next Generation Polymeric Vaccine Adjuvants, Technology J., 2(2014)
K Rajan, Nanoinformatics: Data-Driven Materials Design for Health and Environmental Needs, in Nanotechnology Environmental Health and Safety – 2nd Edition: Eds. M. Hull and D. Bowman: pp. 173-198; Elsevier (2014)
F Jia, B Narasimhan, SK Mallapragada. Materials-based strategies for multi-enzyme immobilization and co-localization: a review, Biotechnol Bioeng 111, 209-222 (2014)
JV Ramirez, J Goodman, R Roychoudhury, P Boggiato, NLB Pohl, MJ Wannemuehler, B Narasimhan. In vivo evaluation of safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles, Trans Soc Biomater, 37, 537 (2014)
Adams J, Goswami M, Pohl N, Mallapragada SK. Synthesis and Functionalization of Virus-Mimicking Cationic Block Copolymers with Pathogen-Associated Carbohydrates as Potential Vaccine Adjuvants. RSC Advances, 2014, 4, 15655-15663.
Phanse, Y., Carrillo-Conde, B. R., Ramer-Tait, A. E., Broderick, S., Kong, C. S., Rajan, K., Flick, R., Mandell, R. B., Narasimhan, B., Wannemuehler, M. J. A systems approach to designing next generation vaccines: combining α-galactose modified antigens with nanoparticle platforms. Scientific Reports, 4, 3775. (2014)
X Liu, Q Ge, A Rawal, G Parada, K Schmidt-Rohr, M Akinc, and SK Mallapragada, Bioinspired Synthesis and Characterization of Mesoporous Zirconia Templated By Cationic Block Copolymers in Aqueous Media, Sci. Adv. Mater., 5, 1-12 (2013)
F Jia, X Liu, L Li, SK Mallapragada, B Narasimhan, and Q Wang, “Multifunctional nanoparticles for targeted delivery of anti-cancer therapeutics and immune activation,” J Contr Rel, 172, 1020-1034 (2013)
Y Phanse, BR Carrillo-Conde, AE Ramer-Tait, R Roychoudhury, NLB Pohl, MJ Wannemuehler, B Narasimhan, and BH Bellaire, Functionalization of polyanhydride microparticles by di-mannose influences their uptake by and intracellular fate within dendritic cells, Acta Biomater, 9(11), 8902-8909 (2013)
LK Petersen, L Huntimer, KA Walz, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan. Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platform for vaccine delivery, Int J Nanomed, 8, 2213-2225 (2013)
F Jia, B Narasimhan, SK Mallapragada. Biomimetic multi-enzyme complexes based on nanoscale platforms, AIChE J, 59(2), 355-360 (2013)
LM Huntimer, JH Wilson-Welder, KA Ross, B Carrillo-Conde, L Pruisner, C Wang, B Narasimhan, MJ Wannemuehler, AE Ramer-Tait. Single immunization of a suboptimal dose of antigen encapsulated into polyanhydride microparticles promotes high titer and avid antibody responses, J Biomed Mater Res B, 101B, 91-98 (2013)
LM Huntimer, AE Ramer-Tait, LK Petersen, KA Ross, KA Walz, C Wang, JM Hostetter, B Narasimhan, MJ Wannemuehler. Evaluation of biocompatibility and administration site reactogenicity of polyanhydride particle-based platform for vaccine delivery, Adv Healthcare Mater, 2, 369-378 (2013)
R Roychoudhury, JE Vela-Ramirez, B Narasimhan, NLB Pohl. Application of a fluorous amine-protecting group in the automated synthesis of oligomannosides for the development of three-component anti-HIV-1 vaccines, Abstracts Papers ACS, 246, 66 (2013)
J Vela-Ramirez, R Roychoudhury, H Habte, M Cho, NL Pohl, MJ Wannemuehler, B Narasimhan, Functionalized polyanhydride nanoparticles preserve protein stability and activate antigen presenting cells, Trans Soc Biomater, 36 (2013)
F Jia, SK Mallapragada, and B Narasimhan, DNA directed multi-enzyme co-localization on nanoparticles, Abstracts Papers ACS, 245, 752 (2013)
H Rosevear, Y Krishnamachari, CA Ariza, SK Mallapragada, A Salem, T Griffith, B De Yound, and M Wald, Effect of Combined Locally Delivered Growth Factors and Systemic Sildenafil Citrate on the Number of Micro-recanals in a Biodegradable Conduit for Reconstruction of the Vas Deferens, Urology, 79, 967 (2012)
F Jia, Y Zhang, B Narasimhan, and SK Mallapragada, Block copolymer-quantum dot micelles for multi-enzyme co-localization, Langmuir, 28, 17389-17395 (2012)
B Carrillo-Conde, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles differentially influences dendritic cell uptake and activation, Acta Biomater, 8, 3618-3628 (2012)
B Carrillo-Conde, R Roychoudhury, AV Chavez-Santoscoy, NLB Pohl, and B Narasimhan, High throughput synthesis of carbohydrates and functionalization of polyanhydride nanoparticles, J Vis Exp, 65, e3967, (2012)
Y Phanse, AE Ramer-Tait, SL Friend, B Carrillo-Conde, P Lueth, CJ Oster, GJ Phillips, B Narasimhan, MJ Wannemuehler, and BH Bellaire, Analyzing cellular internalization of nanoparticles and bacteria by multi-spectral imaging flow cytometry, J Vis Exp. 2012 Jun 8;(64):e3884.
BR Carrillo-Conde, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Effect of chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles on uptake by and activation of dendritic cells, BMES Proceed, 2012
Y Phanse, BR Carrillo-Conde, AE Ramer-Tait, R Roychoudhury, NL Pohl, B Narasimhan, MJ Wannemuehler, BH Bellaire. Uptake and intracellular fate of C-type lectin receptor targeted polyanhydride microparticles, BMES Proceed, 2012
J Vela-Ramirez, H Habte, J Hua, L Tygrett, MW Cho, N Greenspan, T Waldschmidt, and B Narasimhan. Polyanhydride nanoparticle adjuvants stabilize HIV-1 antigens and induce germinal center formation, BMES Proceed, 2012
L Huntimer, AE Ramer-Tait, LK Petersen, KA Ross, KA Walz, C Wang, JM Hostetter, MJ Wannemuehler, B Narasimhan. Enhanced safety profile of polyanhydride nanoparticle vaccine platforms. Trans Soc Biomater, 35 (2012)
Ulery BD, Petersen LK, Phanse Y, Kong CS, Broderick SR, Kumar D, Ramer-Tait AE, Carrillo-Conde B, Rajan K, Wannemuehler MJ, Bellaire BH, Metzger DW, Narasimhan B. Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants. Sci Rep. 1:198. (2011)
B Carrillo-Conde, E-H Song, AV Chavez-Santoscoy, Y Phanse, AE Ramer-Tait, NL Pohl, MJ Wannemuehler, BH Bellaire, and B Narasimhan, Mannose-functionalized “pathogen-like” polyanhydride nanoparticles target C-type lectin receptors on dendritic cells, Mol Pharm. 2011 Oct 3;8(5):1877-86.
LK Petersen, AE Ramer-Tait, SR Broderick, C-S Kong, BD Ulery, K Rajan, MJ Wannemuehler, and B Narasimhan, Activation of innate immune responses in a pathogen-mimicking manner by amphiphilic polyanhydride nanoparticle adjuvants, Biomaterials, 32, 6815-6822 (2011)
LK Petersen, BD Ulery, SR Broderick, Y Phanse, AE Ramer-Tait, CS Kong, BH Bellaire, MJ Wannemuehler, K Rajan, B Narasimhan. Design of “pathogen-mimicking” polyanhydride adjuvants. Trans Soc Biomater, 34 (2011)
MP Torres, J Wilson-Welder, SK Lopac, Y Phanse, B Carrillo-Conde, AE Ramer-Tait, BH Bellaire, MJ Wannemuehler, and B Narasimhan, Polyanhydride microparticles enhance dendritic cell antigen presentation and activation, Acta Biomater, 7, 2857-2864 (2011)
X Li, LK Petersen, SR Broderick, B Narasimhan, and K Rajan, Identifying factors controlling protein release from combinatorial biomaterial libraries via hybrid data mining methods, ACS Comb Chem, 13(1), 50-58 (2011)
JH Wilson-Welder, L Huntimer, KA Ross, BR Carrillo-Conde, L Pruisner, B Narasimhan, and MJ Wannemuehler, Encapsulation of antigens into microparticles results in dosage sparing capabilities. Trans Soc Biomater, 34 (2011)
BR Carrillo-Conde, MJ Wannemuehler, and B Narasimhan, Effect of plasma protein adsorption on in vitro activation of dendritic cells by polyanhydride microparticles, Trans Soc Biomater, 34 (2011)
BR Carrillo-Conde, SJ Seiler, M Dey, AE Ramer-Tait, MJ Wannemuehler, and B Narasimhan, Protein stability upon encapsulation and release from polyanhydride nanoparticles, Trans Soc Biomater, 34 (2011)
SR Broderick, JR Nowers, C Suh, B Narasimhan, and K Rajan, Tracking chemical pathways in combinatorial polymer libraries via data mining, J Comb Chem, 12(2), 270-277 (2010)
Y Zhang, SK Mallapragada, and B Narasimhan, A high throughput method to investigate polymer dissolution, Macromol Rapid Comm, 31(4), 385-390 (2010)
MA Ver Meer, B Narasimhan, BH Shanks, and SK Mallapragada, Effect of mesoporosity on thermal and mechanical properties of polystyrene/silica composites, ACS Appl Mater Interfac, 2(1), 41-47(2010)
LK Petersen, CK Sackett, MJ Wannemuehler, and B Narasimhan, High throughput screening and characterization of polymer nanoparticle adjuvants, Polym Prepr, 240, 137 (2010)
BR Carrillo-Conde, AV Chavez-Santoscoy, E-H Song, Y Phanse, NL Pohl, MJ Wannemuehler, BH Bellaire, and B Narasimhan, Targeting dendritic cells with “pathogen-like” polyanhydride nanoparticles, Trans Soc Biomater, 33 (2010)
LK Petersen, AM Yeager, B Narasimhan, and MJ Wannemuehler, In vitro activation of dendritic cells by polyanhydride nanoparticles, Trans Soc Biomater, 33 (2010)
SK Lopac, MP Torres, JH Wilson-Welder, MJ Wannemuehler, and B Narasimhan, Effect of polymer chemistry and fabrication method on protein release and stability from polyanhydride microspheres, J Biomed Mater Res B, 91(12), 938-947 (2009)
LK Petersen, L Xue, K Rajan, MJ Wannemuehler, and B Narasimhan, The simultaneous effect of polymer chemistry and device geometry on the in vitro activation of murine dendritic cells, Biomaterials, 30, 5131-5142 (2009)
BD Ulery, Y Phanse, A Sinha, MJ Wannemuehler, B Narasimhan, and BH Bellaire, Polymer chemistry influences uptake of nanospheres by immune cells, Pharm Res, 26(3), 683-690 (2009)
JH Wilson-Welder, MP Torres, MJ Kipper, SK Mallapragada, MJ Wannemuehler, and B Narasimhan, Vaccine adjuvants: current challenges and future approaches, J Pharm Sci, 98(4), 1278-1316 (2009)
AF Adler, LK Petersen, JH Wilson, MP Torres, JB Thorstenson, SW Gardner, SK Mallapragada, MJ Wannemuehler, and B Narasimhan, High throughput cell-based screening of biodegradable polyanhydride libraries, Comb Chem High Through Screen, 12(7), 634-645 (2009)
BD Ulery, Y Phanse, A Sinha, MP Torres, BH Bellaire, MJ Wannemuehler, and B Narasimhan, Intracellular trafficking of polyanhydride nanospheres by antigen presenting cells, Trans Soc Biomater, 32 (2009)
Y Phanse, BR Carrillo-Conde, MJ Wannemuehler, B Narasimhan, and BH Bellaire, Polymer chemistry influences uptake and intracellular integrity of polyanhydride microspheres in dendritic cells, Trans Soc Biomater, 32 (2009)
Veterinary diseases
Kingstad-Bakke B, Chandrasekar S, Phanse Y, Ross K, Hatta M, Suresh M, Kawaoka Y, Oshirio J, Narasimhan B, Talaat A. Effective mosaic-based nanovaccines against avian influenza in poultry. Vaccine. 37(35): 5051-5058 (2019)
Guerra-Maupome M, Palmer MV, McGill JL, Sacco RE. Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection. Vaccines (Basel). Jan 8;7(1) (2019)
McGill JL, Kelly SM, Kumar P, Speckhart S, Haughney SL, Henningson J, Narasimhan B, Sacco RE. Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Sci Rep. Feb 14;8(1):3021 (2018)
Schaut RG, Brewer MT, Mendoza K, Jackman J, Narasimhan B, Jones DE. A polyanhydride-based implantable single dose vaccine platform for long-term immunity. Vaccine. Feb 8;36(7):1024-1025 (2018)
Schaut RG, Brewer MT, Hostetter JM, Mendoza K, Vela-Ramirez JE, Kelly SM, Jackman JK, Dell’Anna G, Howard JM, Narasimhan B, Zhou W, Jones DE. A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers. Vaccine. Feb 8;36(7):1016-1023 (2018)
Renu S, Markazi AD, Dhakal S, Lakshmanappa YS, Gourapura SR, Shanmugasundaram R, Senapati S, Narasimhan B, Selvaraj RK, Renukaradhya GJ. Surface engineered polyanhydride-based oral Salmonella subunit nanovaccine for poultry. Int J Nanomedicine Nov 30;13:8195-8215 (2018)
R Schaut, M Brewer, J Hostetter, K Mendoza, J Vela-Ramirez, S Kelly, J Jackman, G Dell’Anna, J Howard, B Narasimhan, W Zhou, D Jones. A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers. Vaccine. 36(7): 1016-1023. (2018)
R Schaut, M Brewer, K Mendoza, J Jackman, G Dell’Anna, B Narasimhan, D Jones. A polyanhydride-based implantable single dose vaccine platform for long-term immunity. Vaccine. 36(7): 1024-5. (2018)
Sponseller BA, Clark SK, Gilbertie J, Wong DM, Wiechert S, Chandramani P, Sponseller BT, Alcott CJ, Bellaire B, Petersen AC, Jones DE. Macrophage effector responses of horses are influenced by expression of CD154. Vet Immunol Immunopathol. 180:40-44. (2016)
Grinnage-Pulley, T., Scott, and C. A. Petersen. A mother’s gift: Congenital transmission of Trypanosoma and Leishmania species. PLoS Pathogens. Jan 28;12(1):e1005302. (2016)
McGill JL, Rusk RA, Guerra-Maupome M, Briggs RE, Sacco RE. Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica. PLoS One. 11(3):e0151083. (2016)
McGill JL, Sacco RE. γσ T cells and the immune response to respiratory syncytial virus infection. Vet Imunol Immunopathol. 181:24-29. (2016)
Schaut, R., Robles-Murguia, M., Juelsgaard, R., Esch, K.J., Bartholomay, L., Ramalho-Ortigao, M, Petersen, C. Vectorborne Transmission of Leishmania infantum from Hounds, U.S. Emerging Infectious Diseases, Dec.; 21(12):2209-2212 (2015)
Eberle KC, Neill JD, Venn-Watson SK, McGill JL, Sacco RE. Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains. Virus Genes. 51(2): 198-208. (2015)
Schaut RG, McGill JL, Neill JD, Ridpath JJF, Sacco RE. Bovine viral diarrhea virus type 2 in vivo infections modulates TLR4 responsiveness in differentiated myeloid cells which is associated with decreased MyD88 expression. Virus Res. 208:44-55. (2015)
Olsen SC, McGill JL, Sacco RE, Hennager SG. Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51. Clin Vaccine Immunol. 22(4):440-7.(2015)
Grinnage-Pulley, T., Petersen, CA., Blood Parasites: Trypanosomiasis. In: The Merck Veterinary Manual (2015)
Nonnecke BJ, McGill JL, Ridpath JF, Sacco RE, Lippolis JD, Reinhardt TA. Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves. J Dairy Sci. 97(9): 5566-79. (2014)
Plattner BL, Huffman E, Jones DE, Hostetter JM. T lymphocyte responses during early enteric Mycobacterium avium subspecies paratuberculosis infection in cattle. Vet Immunol Immunopathol. 157(1-2): 112-9. (2014)