Associate Director, Nanovaccine Institute
Professor and Chairman
Biochemistry & Molecular Biology, Eppley Cancer Institute
University of Nebraska Medical Center
Omaha, NE 68198
Tumor-associated genes; cancer diagnostics, cancer vaccines; monoclonal antibodies, genetic engineering of antibodies
The overall goals of our laboratory are to study the molecular mechanisms of neoplastic transformation, differentiation, and altered-growth in human pancreatic, ovarian and prostate tumors. Normal cell proliferation is under the intrinsic control of growth-promoting proto-oncogenes and growth-constraining anti-oncogenes.
Specifically, we are defining multifaceted roles of tumor associated antigens (MUC4 and PD2/hPaf1) in the pathogenesis of pancreatic, breast, ovarian and prostate cancers.
Ph.D., NDRI (Kurukshetra Univ.), India, 1983