June 18, 2014
“Nanovaccines, Nanocarriers, and Ultra-Sensitive Diagnostic Systems for Human Health Management”
|Dr. Ashok Ganguli
Institute of Nanoscience & Technology
Mohali, Punjab, India
The Institute of Nanoscience & Technology is developing nanovaccines, novel nanocarriers, and ultra-sensitive diagnostic systems against important diseases. We are working on mucosal cell line targeting lipo-peptide nanostructures with multiple viral epitopes for their potential to deliver antiviral therapeutics. One group is investigating needle-free vaccination for Dengue virus by encapsulating recombinant Dengue virus protein with novel adjuvants in biodegradable nanoparticles, which will evoke TLR9 activating and induce a high level of antigen-specific IgG in serum. We are also exploring nanocomposites for anti-HIV drug delivery that will effectively cross the blood-brain barrier and target HIV-infected macrophages in the brain to prevent neuroAIDS and other neurological disorders. We are evaluating the neurotoxicity profile of selected nanostructures by studying their accumulation in the brain and studying their action mechanism of inducing neurotoxicity, neuronal apoptosis, oxidative stress, neuro-histopathological alterations, and long-term neuro-behavioral outcomes. Another group at INST is working on early detection of selected human diseases, paving the way for non-conventional theranostics management. They are developing rapid, quantitative, and cost-effective diagnostic tests using specific bioreceptors-functionalized paper/plastic substrates impregnated with electrochemical sensors. These sensors can be used in physicians’ offices, clinics, emergency rooms, operating rooms, and even at patient bedside.
Dr. Ganguli received his MSc in Chemistry from the University of Delhi and his PhD from the Indian Institute of Science, Bangalore. He did post-doctoral work in the U.S. at DuPont and the Ames Laboratory. He joined the India Institute of Technology, Delhi in 1995, where he is a Professor of Chemistry. Since 2013 he has also served as Director of the Institute of Nanoscience & Technology in Mohali. His research areas include designing nanostructures using microemulsions for applications in photocatalysis, photovoltaics, efficient electrocatalysis for hydrogen and oxygen evolution reactions, and porous functionalised nanostructures for toxin removal and water purification. His other major research interest is in the field of high temperature superconductors.