March 5, 2015
co-sponsored with the Department of Biomedical Sciences
“Vaccine Studies to Mitigate Influenza in a Pig Model”
Food Animal Health Research Program
Dr. Renukaradhya Gourapura’s laboratory research focus is on mucosal immunology of food animals infected with infectious and zoonotic diseases. Unlike systemic delivery, mucosal delivery (intranasal) of potent vaccines increases the breadth of cross-protective immunity against infections which cause disease primarily at mucosal sites. My presentation covers the strategies adapted to potentiate cross-protective efficacy of candidate inactivated virus vaccines in a pig model. We used biodegradable nanoparticle and adjuvant based intranasal delivery system to elicit strong immunity at both mucosal and systemic sites against porcine reproductive and respiratory syndrome (PRRS) and influenza viruses. Results of our study are encouraging to promote pig as a potential animal model for biomedical research to develop nanotechnology-based vaccines to improve human health.
Dr. Gourapura received his Doctor of Veterinary Medicine degree in Veterinary Science from the University of Agricultural Sciences and his PhD in Microbiology and Cell Biology from the Indian Institute of Science, both in Bangalore, India. He served as a National Research Services Award Trainee in Indiana University’s School of Medicine before joining the Ohio State University as a faculty member in the Food Animal Health Research Program and Ohio Agricultural Research and Development Center. His research involves developing and testing influenza virus M2e-based vaccines in mice and pigs, evaluating the effectiveness of intranasal nanovaccination in pigs, and developing strategies to enhance PRRS- specific innate and mucosal immunity in pigs. In recent years, Dr. Gourapura co-wrote several book chapters in the areas of immunology and vaccinology, and co-patented methods for treating and preventing porcine reproductive and respiratory syndrome.